Related Experiment Video
Updated: Sep 3, 2025
14:24
Percutaneous Contrast Echocardiography-guided Intramyocardial Injection and Cell Delivery in a Large Preclinical Model
Published on: January 21, 2018
11.8K
Cancer treatment-related cardiac dysfunction
Bernadette Brady1,2, Ross Murphy3
1Academic Department of Palliative Medicine, Our Lady's Hospice & Care Services, Dublin, Ireland bbrady@olh.ie.
BMJ Supportive & Palliative Care
|July 26, 2022
Summary
Early detection and management of cancer treatment-related cardiac dysfunction (CTRCD) are crucial. Supportive care clinicians play a key role in identifying and monitoring long-term cardiac sequelae in cancer survivors.
Area of Science:
- Cardiology
- Oncology
- Palliative Care
Background:
- Cancer treatments can lead to cardiotoxicity and cancer treatment-related cardiac dysfunction (CTRCD).
- Long-term cardiac sequelae of cancer therapies are increasingly recognized.
- These effects may emerge during supportive care or survivorship.
Purpose of the Study:
- To describe cardiotoxicity and CTRCD.
- To provide key messages for supportive and palliative care clinicians.
- To facilitate the identification and management of CTRCD.
Main Methods:
- Review of cardiotoxicity types and cardiac complications of cancer therapies.
- Highlighting challenges in autonomic nervous system dysfunction in cancer patients.
- Outlining management strategies for cardiotoxicity.
Main Results:
- Cardiotoxicity presents in various forms.
- Immunotherapy can cause specific cardiac complications.
- Autonomic nervous system dysfunction poses a challenge in cancer care.
Conclusions:
- Early detection of cardiotoxicity is essential.
- Monitoring for CTRCD during cancer treatment is vital.
- Surveillance in survivorship is critical for long-term cardiac health.
Related Concept Videos
01:30Cardiomyopathy II: Dilated Cardiomyopathy
20
Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
20
01:29Cardiomyopathy VI: Nursing Management
28
Assessment: Nursing management of patients with cardiomyopathy begins with a thorough assessment of the patient's history, including a family history of cardiomyopathy or sudden cardiac death, personal history of heart disease, hypertension, diabetes, and any alcohol consumption or drug use.During the physical examination, assess vital signs, look for signs of heart failure (such as edema, jugular venous distention, and cyanosis), auscultate for abnormal heart sounds (like murmurs and gallops),...
28
01:29Cardiomyopathy III: Hypertrophic Cardiomyopathy
43
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
43
01:29Cardiomyopathy IV: Restrictive Cardiomyopathy
23
Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
23
01:26Imbalances in Cardiac Output
1.5K
The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
1.5K
01:29Cardiomyopathy V: Interprofessional Care
30
Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
30