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Microsurgical Creation of Giant Bifurcation Aneurysms in Rabbits for the Evaluation of Endovascular Devices
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CLinical Assessment of WEB device in Ruptured aneurYSms (CLARYS): 12-month angiographic results of a multicenter

Laurent Spelle1,2, Denis Herbreteau3, Jildaz Caroff4,5

  • 1NEURI Brain Vascular Center, Interventional Neuroradiology, Bicetre University Hospital, Le Kremlin-Bicetre, France laurent@spelle.fr.

Journal of Neurointerventional Surgery
|July 26, 2022
PubMed

Insights

The Woven EndoBridge (WEB) device offers safe and effective endovascular treatment for ruptured bifurcation aneurysms, demonstrating good occlusion rates at 1-year follow-up. This approach provides reliable protection against rebleeding in patients with these complex cerebrovascular conditions.

Area of Science:

  • Neurosurgery
  • Interventional Neuroradiology
  • Vascular Surgery

Background:

  • The CLinical Assessment of WEB device in Ruptured aneurYSms (CLARYS) study previously established the safety and efficacy of the Woven EndoBridge (WEB) device for ruptured bifurcation aneurysms.
  • The study demonstrated protection against rebleeding at 1-month and 1-year follow-up, highlighting the importance of 12-month angiographic assessment.

Purpose of the Study:

  • To evaluate the 12-month angiographic outcomes of endovascular treatment for ruptured bifurcation aneurysms using the Woven EndoBridge (WEB) device.
  • To assess the occlusion rates and safety profile of the WEB device in this patient cohort.

Main Methods:

  • A prospective, multicenter study involving 60 patients with 60 ruptured bifurcation aneurysms across 13 European centers.
  • Independent assessment of safety outcomes and imaging, with 46 patients undergoing 12-month follow-up imaging.

Main Results:

  • At 1-year, complete occlusion (Raymond-Roy grade I) was achieved in 41.3% (19/46) of aneurysms, with residual neck in 45.7% (21/46) and residual aneurysm filling in 13.0% (6/46).
  • Adequate occlusion, defined as grade I or II, was reported in 87% (40/46) of aneurysms. Six patients required retreatment.
  • The majority of treated aneurysms (88.3%) had a broad base and a low dome-to-neck ratio (<2).

Conclusions:

  • The Woven EndoBridge (WEB) device provides effective endovascular treatment for ruptured bifurcation aneurysms, with a favorable safety profile and protection against rebleeding.
  • The 1-year angiographic occlusion rates achieved with the WEB device are comparable to those reported in studies of unruptured aneurysms.
Abstract

Keywords:
AneurysmAngiographyDeviceInterventionSubarachnoid

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