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Gut microbiome and aging nexus and underlying mechanism
Xuan Shi1,2,3, Teng Ma1,2,3, Hafiz Arbab Sakandar1,2,3
1Inner Mongolia Key Laboratory of Dairy Biotechnology and Engineering, Inner Mongolia Agricultural University, Hohhot, Inner Mongolia, China.
Applied Microbiology and Biotechnology
|July 26, 2022
Summary
The gut microbiome differs in centenarians, offering insights into healthy aging. Research explores dietary interventions, fecal transplants, and probiotics to promote longevity through gut microbiota management.
Area of Science:
- Gerontology and Microbiology
- Focus on the gut microbiome's role in aging and longevity.
Background:
- Global population aging necessitates focus on senior nutrition and health.
- Gut microbiota is crucial for human health, with unique profiles in centenarians.
Purpose of the Study:
- To review the significance of gut microbiota in human health.
- To describe gut microbiota characteristics in long-lived individuals across different regions.
- To explore interventions for modulating gut microbiota to promote healthy aging and longevity.
Main Methods:
- Literature review on gut microbiota composition in various age groups and centenarians.
- Analysis of dietary interventions, fecal microbiota transplantation, and probiotic applications.
- Discussion of the benefits and drawbacks of probiotic use for elderly gut health.
Main Results:
- Centenarians exhibit distinct gut microbial structures compared to the general elderly population.
- Common characteristics of centenarian gut microbiomes across different countries are identified.
- Interventions like diet, FMT, and probiotics can modulate gut microbiota for health benefits.
Conclusions:
- Gut microbiota plays a vital role in healthy aging and longevity.
- Targeted management of gut microbiota holds promise for promoting healthspan in seniors.
- Further research is needed to elucidate the mechanisms linking gut microbiota, probiotics, and longevity.
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