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Bacillus coagulans TBC169 probiotics for the recovery of intestinal function after gynecological laparoscopic
Zhihong Li1,2, Zhaobo Guan3,4, Niuniu Bai3,4
1Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan, 030032, China.
Insights
Bacillus coagulans TBC169 probiotics significantly accelerated intestinal function recovery and reduced adverse events in patients undergoing gynecological laparoscopic surgery. This probiotic intervention improved key recovery markers like time to first flatus and bowel sounds.
Area of Science:
- Gastroenterology
- Microbiology
- Surgical Recovery
Background:
- Bacillus coagulans TBC169 is known to enhance intestinal motility.
- Postoperative ileus is a common complication following gynecological laparoscopic surgery, impacting recovery and hospital stay.
Purpose of the Study:
- To evaluate the efficacy and safety of Bacillus coagulans TBC169 in accelerating intestinal function recovery after gynecological laparoscopic surgery.
- To assess the impact of Bacillus coagulans TBC169 on reducing postoperative adverse events.
Main Methods:
- A randomized controlled trial involving patients undergoing gynecological laparoscopic surgery.
- Participants were assigned to high-dose, conventional-dose Bacillus coagulans TBC169, or placebo groups.
- Primary outcome: time to first passage of flatus (FFT); Secondary outcomes: time to first defecation (FDT), time to first bowel sounds (TFBS), duration of hospital stay (DHS), and incidence of adverse events (AEs).
Main Results:
- Both conventional and high doses of Bacillus coagulans TBC169 significantly reduced FFT and TFBS compared to placebo (P < 0.05 and P < 0.001, respectively).
- The incidence of postoperative adverse events was significantly lower in both Bacillus coagulans TBC169 groups compared to placebo (P < 0.05 and P < 0.001, respectively).
- No significant differences were observed in FFT or TFBS between the conventional and high-dose groups, nor in the incidence of AEs between the intervention groups.
Conclusions:
- Bacillus coagulans TBC169 probiotics effectively accelerate intestinal function recovery post-gynecological laparoscopic surgery.
- Administration of Bacillus coagulans TBC169 probiotics can reduce the incidence of postoperative adverse events.
- The findings support the use of Bacillus coagulans TBC169 as a therapeutic option for improving surgical recovery in gynecology.
Background:
Evidence suggests that Bacillus coagulans TBC169 can improve intestinal motility.
Aim:
To investigate the effectiveness and safety of Bacillus coagulans TBC169 probiotics in promoting the recovery of intestinal function after gynecological laparoscopic surgery.
Method:
Patients who underwent laparoscopic surgeries due to gynecological diseases were randomly assigned to the high-dose, conventional-dose, and the placebo-control groups (1:1:1 ratio). The primary outcome was the time to the first passage of flatus time (FFT). Secondary outcomes were the time to the first defecation (FDT), the time to the first bowel sounds (TFBS), the duration of hospital stay (DHS), and the incidence of postoperative adverse events (AEs).
Results:
Compared to the placebo-control group, shorter FFT values were observed in the conventional-dose (23.15 h vs. 29.10 h, P < 0.05) and high-dose (19.15 h vs. 29.10 h, P < 0.001) groups. Similar trends were observed regarding TFBS in the conventional-dose (18.50 h vs. 21.10 h, P < 0.05) and high-dose (15.20 h vs. 21.10 h, P < 0.001) groups. There were no significant differences in FFT and TFBS between the intervention groups. Compared to the placebo-control group, lower incidences of postoperative adverse events were observed in the conventional-dose (12.50% vs. 40.00%, P < 0.05) and the high-dose (5.00% vs. 40.00%, P < 0.001) groups. However, there were no significant differences between these intervention groups.
Conclusion:
Bacillus coagulans TBC169 probiotics can accelerate intestinal function recovery, and reduce postoperative adverse events in patients after gynecological laparoscopic surgery. The study protocol was registered at the Chinese Clinical Trial Registry (ChiCTR2200059518).
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