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[In vitro bleeding time].

S Bellucci, E Cambau, B Candalot

    Nouvelle Revue Francaise D'Hematologie
    |January 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    An in vitro bleeding time (BT) model accurately predicts in vivo results, offering a repeatable method for monitoring haemostasis and evaluating drug effects on primary haemostasis.

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    Area of Science:

    • Hematology
    • Physiology

    Context:

    • Primary haemostasis is crucial for stopping bleeding.
    • Assessing primary haemostasis is essential for clinical management and drug development.

    Purpose:

    • To evaluate an in vitro model of primary haemostasis (bleeding time, BT).
    • To determine the correlation between in vitro BT and in vivo BT.
    • To assess the utility of in vitro BT for monitoring haemostasis and drug effects.

    Summary:

    • An in vitro bleeding time (BT) model, based on Kratzer and Born methods, was studied.
    • A significant correlation was found between the in vitro BT and in vivo BT.
    • The in vitro BT demonstrated high repeatability within the same patient.

    Impact:

    • This in vitro BT model provides a reliable tool for assessing primary haemostasis.
    • It facilitates patient haemostasis monitoring and control.
    • The model allows for in vitro and ex vivo studies of drug impacts on primary haemostasis.