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Updated: Sep 3, 2025

Cycloheximide Chase Analysis of Protein Degradation in Saccharomyces cerevisiae
Published on: April 18, 2016
The Multifaceted Role of the Ubiquitin Proteasome System in Pathogenesis and Diseases
Zane Stekel1, Yi Sheng2, Wei Zhang1,3
1Department of Molecular and Cellular Biology, College of Biological Science, University of Guelph, 50 Stone Rd. E, Guelph, ON N1G 2W1, Canada.
Abstract:
Ubiquitin is a small protein that is conjugated to target proteins to signal a great number of critical biological processes. Impaired ubiquitin signaling and defects in the ubiquitin proteasome system (UPS) surveillance are implicated in many human diseases, including cancer. Characterization of the physiological roles of UPS components and their regulatory mechanisms is therefore vital for the identification of therapeutic targets and the development of tools and paradigms to better understand and treat human diseases. In this Special Issue, we assembled seven original research and review articles to provide insights on the multifaceted role of the UPS in pathogenesis and disease, covering the areas of molecular and cellular mechanisms of UPS enzymes, biochemical and biophysical characterization strategies, drug development, and targeted protein degradation.
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