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Src Family Kinases: A Potential Therapeutic Target for Acute Kidney Injury

Nannan Li1, Guoxin Lin2, Hao Zhang1

  • 1Department of Nephrology, The Third Xiangya Hospital, Central South University, Changsha 410013, China.

Biomolecules
|July 27, 2022
PubMed

Insights

Src family kinases (SFKs) are crucial in kidney injury. Targeting SFKs like Src, Fyn, and Lyn offers a promising therapeutic strategy for acute kidney injury (AKI).

Area of Science:

  • Molecular Biology
  • Nephrology
  • Biochemistry

Background:

  • Src family kinases (SFKs) are non-receptor tyrosine kinases vital for signal transduction.
  • SFKs, including Src, Fyn, and Lyn, are increasingly implicated in kidney disease pathogenesis.
  • Acute kidney injury (AKI) involves complex mechanisms like oxidative stress, inflammation, ER stress, autophagy, and apoptosis, often leading to fibrosis and chronic kidney disease (CKD).

Purpose of the Study:

  • To review the structure, function, and role of SFKs in the context of AKI.
  • To highlight SFKs as potential therapeutic targets for AKI treatment.

Main Methods:

  • Literature review and synthesis of existing research on SFKs and AKI.

Main Results:

  • SFKs play a significant role in the development and progression of AKI.
  • Specific SFKs, notably Src, Fyn, and Lyn, are involved in AKI pathogenesis.

Conclusions:

  • SFKs are critical mediators in AKI.
  • Targeting SFKs presents a promising avenue for developing novel AKI therapeutics.
Keywords:
ER stressSrc family kinasesacute kidney injuryautophagyfibrosisinflammationoxidative stress

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