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Evaluation of the Storage Stability of Extracellular Vesicles
11:31

Evaluation of the Storage Stability of Extracellular Vesicles

Published on: May 22, 2019

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Extracellular Vesicles, Inflammation, and Cardiovascular Disease

Akbarshakh Akhmerov1, Tanyalak Parimon2

  • 1Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.

Cells
|July 27, 2022
PubMed

Insights

Extracellular vesicles play a key role in cardiovascular disease by mediating inflammatory responses. This review details their involvement in conditions like atherosclerosis and heart failure.

Area of Science:

  • Immunology
  • Cardiology
  • Molecular Biology

Background:

  • Cardiovascular disease (CVD) is a major global health concern.
  • Immune responses, both innate and adaptive, are central to CVD pathogenesis.
  • Extracellular vesicles (EVs) are increasingly recognized for their roles in intercellular communication, including in immune processes.

Purpose of the Study:

  • To elucidate the mechanistic role of extracellular vesicles (EVs) in cardiovascular disease.
  • To explore the intersection of EV-mediated inflammation and various cardiovascular pathologies.
  • To provide a comprehensive overview of EV involvement in CVD.

Main Methods:

  • Literature review and synthesis of existing research.
  • Focus on mechanistic insights into EV function in cardiovascular contexts.
  • Discussion of EVs in specific cardiovascular diseases.

Main Results:

  • Extracellular vesicles are implicated in both innate and adaptive immune responses relevant to CVD.
  • EVs contribute to the inflammatory processes underlying atherosclerosis.
  • EVs play roles in myocardial ischemia, heart failure, aortic aneurysms, and valvular pathology.

Conclusions:

  • Extracellular vesicles are critical mediators at the nexus of inflammation and cardiovascular disease.
  • Understanding EV function offers potential therapeutic targets for cardiovascular disorders.
  • Further research into EVs is warranted to fully leverage their diagnostic and therapeutic potential in cardiology.

Keywords:
adaptive immunitycardiac diseasecardiovascular diseaseexosomesextracellular vesiclesheart diseaseinflammationinnate immunitymicrovesiclesmyocardium

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