Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

554
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
554
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

422
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
422
Antiasthma Drugs: Leukotriene Modifiers01:19

Antiasthma Drugs: Leukotriene Modifiers

432
Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:
432
Asthma-I: Introduction01:29

Asthma-I: Introduction

2.8K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
2.8K
Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

2.6K
The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
2.6K
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

2.8K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
2.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Role of Polyunsaturated Fatty Acids (PUFAs) in the Primary Prevention of Allergic Diseases in Children: A Position Paper of the SIAIP Primary and Secondary Prevention of Allergic Diseases and Nutraceuticals Committees.

Nutrients·2026
Same author

Ibuprofen vs. acetaminophen for acute mild-to-moderate pain management: A systematic review and meta-analysis of safety with a focus on paediatric populations.

British journal of clinical pharmacology·2026
Same author

The Evaluation initiative: management of rhinitis by Italian otorhinolaryngologists.

Multidisciplinary respiratory medicine·2026
Same author

Type 2 inflammation and biologics: a twenty-year journey.

Expert opinion on biological therapy·2026
Same author

Biological drugs for the treatment of children with atopic dermatitis.

Expert opinion on biological therapy·2026
Same author

Novelties in the pragmatic management of anaphylaxis in pediatric age.

European journal of pediatrics·2026

Related Experiment Video

Updated: Sep 3, 2025

Probiotic Studies in Neonatal Mice Using Gavage
10:36

Probiotic Studies in Neonatal Mice Using Gavage

Published on: January 27, 2019

19.8K

Probiotics in Children with Asthma.

Giorgio Ciprandi1, Maria Angela Tosca2

  • 1Allergy Clinic, Casa di Cura Villa Montallegro, 16146 Genoa, Italy.

Children (Basel, Switzerland)
|July 27, 2022
PubMed
Summary

Oral probiotics may help prevent asthma and wheezing relapses in children by rebalancing the immune system and gut microbiota. Specific probiotic strains, like those studied in PROPAM, show promise as an add-on therapy.

Keywords:
add-on therapyasthmaasthma exacerbationoral probioticswheezing

More Related Videos

Investigating the Effects of Probiotics on Pneumococcal Colonization Using an In Vitro Adherence Assay
09:20

Investigating the Effects of Probiotics on Pneumococcal Colonization Using an In Vitro Adherence Assay

Published on: April 28, 2014

12.7K
Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
05:31

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels

Published on: August 7, 2017

10.5K

Related Experiment Videos

Last Updated: Sep 3, 2025

Probiotic Studies in Neonatal Mice Using Gavage
10:36

Probiotic Studies in Neonatal Mice Using Gavage

Published on: January 27, 2019

19.8K
Investigating the Effects of Probiotics on Pneumococcal Colonization Using an In Vitro Adherence Assay
09:20

Investigating the Effects of Probiotics on Pneumococcal Colonization Using an In Vitro Adherence Assay

Published on: April 28, 2014

12.7K
Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
05:31

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels

Published on: August 7, 2017

10.5K

Area of Science:

  • Immunology
  • Microbiology
  • Pediatrics

Background:

  • Childhood asthma and wheezing are often linked to type-2 immune responses and gut/respiratory dysbiosis.
  • Dysbiosis, an imbalance in microbial communities, is frequently observed in children with wheezing and asthma.
  • Airway inflammation is a key characteristic of asthma, contributing to persistent symptoms.

Purpose of the Study:

  • To investigate the potential of probiotics in managing childhood asthma and wheezing.
  • To explore if probiotics can correct immune imbalances and microbial dysbiosis associated with these conditions.
  • To evaluate the efficacy of specific probiotic strains in preventing asthma exacerbations and wheezing episodes.

Main Methods:

  • The study focused on the PROPAM trial, which examined the effects of specific probiotic strains.
  • Participants included children diagnosed with asthma or recurrent wheezing.
  • Outcomes measured included asthma exacerbations, wheezing episodes, and immune markers.

Main Results:

  • Two specific oral probiotic strains demonstrated a significant reduction in asthma exacerbations and wheezing episodes.
  • Probiotics showed potential in rebalancing the immune response and mitigating airway inflammation.
  • Evidence suggests probiotics can help repair dysbiosis in the digestive and respiratory tracts.

Conclusions:

  • Oral probiotics can be a valuable add-on therapy for managing asthma in children.
  • The selection of probiotic strains should be guided by documented clinical evidence of efficacy.
  • Probiotics offer a potential strategy to prevent asthma and wheezing relapses in pediatric populations.