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Elevated Mortality Risk from CRKp Associated with Comorbidities: Systematic Review and Meta-Analysis
Lucas Candido Gonçalves Barbosa1, José Arthur Silva E Sousa2, Graziela Picciola Bordoni1
1Institute of Tropical Pathology and Public Health, Federal University of Goiás (UFG), 235 Street, Neighborhood: Leste Universitário, Goiânia 74605-050, Brazil.
Carbapenem-resistant Klebsiella pneumoniae (CRKP) significantly increases mortality, especially when combined with chronic diseases like kidney, lung, or liver conditions. The risk of death from CRKP is double that of carbapenem-sensitive strains.
Area of Science:
- Infectious Diseases
- Public Health
- Critical Care Medicine
Background:
- Carbapenem-resistant Klebsiella pneumoniae (CRKP) presents a significant global health challenge due to limited treatment options and high mortality rates.
- Comorbidities exacerbate the severity and outcomes of CRKP infections.
Purpose of the Study:
- To systematically review and meta-analyze the mortality associated with carbapenem-resistant Klebsiella pneumoniae (CRKP) infections.
- To assess the impact of comorbidities on mortality in patients with CRKP.
Main Methods:
- A systematic review and meta-analysis of studies from PubMed, SciELO, and Lilacs.
- Inclusion of cohort, case-control, and cross-sectional studies.
- Statistical analysis of mortality proportions and relative risk (RR) using Rstudio® software.
Main Results:
- CRKP infections were associated with substantial mortality across various comorbidities.
- Specific mortality rates were noted for associations with chronic kidney disease (49%), diabetes (29%), and liver disease (33%).
- The relative risk of death from CRKP was significantly higher (RR = 2.07, p < 0.00001) compared to carbapenem-sensitive Klebsiella pneumoniae.
Conclusions:
- Comorbidities significantly increase mortality in patients with carbapenem-resistant Klebsiella pneumoniae infections.
- CRKP poses a heightened mortality risk, underscoring the need for effective therapeutic strategies and infection control.
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