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Updated: Sep 3, 2025

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Published on: August 30, 2018
Advocacy for Responsible Antibiotic Production and Use
Véronique Mondain1, Nicolas Retur2, Benjamin Bertrand3
1Centre Hospitalo-Universitaire de Nice, Service des Maladies Infectieuses et Tropicales, Hôpital Archet 1, 06202 Nice, France.
Abstract:
Antibiotic-resistant bacteria have become one of humankind's major challenges, as testified by the UN's Call to Action on Antimicrobial Resistance in 2021. Our knowledge of the underlying processes of antibiotic resistance is steadily improving. Beyond the inappropriate use of antimicrobials in human medicine, other causes have been identified, raising ethical issues and requiring an approach to the problem from a "One Health" perspective. Indeed, it is now clear that the two main issues regarding the subject of antibiotics are their misuse in the global food industry and their method of production, both leading to the emergence and spread of bacterial resistance.
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