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Related Experiment Video

Updated: Sep 3, 2025

Monitoring Conformational Dynamics of Single Unmodified Proteins using Plasmonic Nanotweezers

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Published on: March 21, 2025

Highly Sensitive Plasmonic Waveguide Biosensor Based on Phase Singularity-Enhanced Goos-Hänchen Shift.

Manel Hedhly^1,2, Yuye Wang^1,3,4, Shuwen Zeng^1,5

¹XLIM Research Institute, UMR 7252 CNRS/University of Limoges, 123 Avenue Albert Thomas, 87060 Limoges, France.

|July 27, 2022

Summary

This summary is machine-generated.

This study introduces a novel plasmonic biosensor for detecting small molecules. The symmetric metal cladding plasmonic waveguide (SMCW) sensor achieves ultra-high sensitivity for biomolecule detection.

Keywords:

optical sensor plasmonic waveguide surface plasmon resonance biosensors

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Area of Science:

Nanotechnology
Biomedical Engineering
Optics

Background:

Detecting small molecules at low concentrations is a significant challenge for existing chemical and biological sensors.
Traditional Surface Plasmon Resonance (SPR) sensing techniques struggle with low molecular weight biomolecules.

Purpose of the Study:

To design and demonstrate a highly sensitive plasmonic biosensor for detecting biomolecules, especially small ones.
To leverage the Goos-Hänchen effect in a novel waveguide structure for enhanced sensing capabilities.

Main Methods:

Designed a symmetric metal cladding plasmonic waveguide (SMCW) structure.
Precisely controlled the configuration and guiding layer thickness to excite ultra-high order modes.
Measured the lateral position shift of the reflected signal using a position sensor.

Main Results:

Achieved a lateral position signal change > 90 µm for glycerol (sensitivity figure-of-merit of 2.33 × 10^4 µm/RIU).
Detected 10⁻⁴ M biotin (a low molecular weight biomolecule) with a > 15 µm lateral position shift.
Improved lateral position shift from 14.17 µm to 284 µm compared to conventional SPR substrates.

Conclusions:

The developed SMCW plasmonic biosensor offers ultra-high sensitivity for detecting ultra-small biological molecules.
This technique shows significant potential for advancing biomedical and clinical diagnostics.
This represents the first experimental study utilizing this specific SMCW configuration for biosensing.