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Updated: Sep 3, 2025

Translating Extracellular Electron Transfer Activities with Organic Electrochemical Transistors
Published on: January 31, 2025
Generalized Analytical Model for Enzymatic BioFET Transistors
Cristian Ravariu1, Avireni Srinivasulu2,3, Dan Eduard Mihaiescu4
1BioNEC Group, Department of Electronic Devices Circuits and Architectures, Faculty of Electronics ETTI, Polytechnic University of Bucharest, Splaiul Independentei 313, 060042 Bucharest, Romania.
Abstract:
Software tools that are able to simulate the functionality or interactions of an enzyme biosensor with Metal Oxide Semiconductor (MOS), or any Field Effect Transistor (FET) as transducer, represent a gap in the market. Bio-devices, or Enzyme-FET, cannot be simulated by Atlas or equivalent software. This paper resolves this issue for the enzymatic block coupled with FETs' role within biosensors. The first block has the concentration of biological analyte as the input signal and concentration of ions from the enzymatic reaction as the output signal. The modeling begins from the Michaelis-Menten formalism and analyzes the time dependence of the product concentrations that become the input signal for the next FET block. Comparisons within experimental data are provided. The analytical model proposed in this paper represents a general analytical tool in the design stage for enzymatic transistors used in clinical practices.
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