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PC-12 Cell Line as a Neuronal Cell Model for Biosensing Applications.
Daniela Oprea1, Caroline G Sanz1, Madalina M Barsan1
1National Institute of Materials Physics, Atomistilor 405A, 077125 Magurele, Romania.
Biosensors
|July 27, 2022
Summary
PC-12 cells are crucial for biosensing due to their neuronal traits. This review covers biosensor applications in PC-12 cell cultures and modern neuronal network biosensing approaches.
Area of Science:
- Neuroscience
- Biomedical Engineering
- Biosensor Technology
Background:
- PC-12 cells are a widely used neuronal model in biosensing devices.
- Their neurogenic characteristics, including neurite outgrowth and neurotransmitter secretion, make them ideal for neuroscience research.
- PC-12 cells are extensively studied for neurotoxicity, neuroprotection, and neurosecretion, aiding in understanding brain disorder pathophysiology.
Purpose of the Study:
- To summarize the applications of various biosensors in PC-12 cell cultures.
- To present modern approaches in neuronal network biosensing using PC-12 cells.
Main Methods:
- Review of analytical technologies for physicochemical processes.
- Focus on optical and electrochemical biosensing techniques.
- Examination of biosensor applications in PC-12 cell cultures.
Main Results:
- PC-12 cells possess key neurogenic characteristics suitable for biosensing.
- Biosensors, particularly optical and electrochemical types, are effective for analyzing PC-12 cell functions.
- Modern biosensing approaches are advancing the study of neuronal networks.
Conclusions:
- Biosensors play a vital role in studying PC-12 cell behavior and neuronal networks.
- Continued development of biosensing technologies will enhance neuroscience research.
- PC-12 cells remain a valuable model for investigating brain disorders and developing therapeutic strategies.
