Biosensors and Microfluidic Biosensors: From Fabrication to Application
Madhusudan B Kulkarni1, Narasimha H Ayachit2, Tejraj M Aminabhavi2
1School of Electronics and Communication Engineering, KLE Technological University, Hubballi 580023, Karnataka, India.
Biosensors
|July 27, 2022
Summary
Microfluidic biosensors offer a miniaturized, mobile, and stable alternative to bulky conventional devices. This review explores their design, advances, and challenges for point-of-care applications.
Area of Science:
- Biomedical Engineering
- Analytical Chemistry
- Materials Science
Background:
- Biosensors are vital across diverse fields like healthcare and environmental monitoring.
- Conventional biosensors often face limitations such as bulkiness, high cost, and slow operation.
- Microfluidics presents a promising approach for developing miniaturized biosensors.
Purpose of the Study:
- To review the design, classification, and recent advances in microfluidic-based biosensors.
- To discuss the challenges and value chain in developing miniaturized microfluidic biosensor devices.
- To highlight the application of these biosensors in various point-of-care testing scenarios.
Main Methods:
- Exploration of microfluidic principles for biosensor operation.
- Analysis of fabrication strategies for miniaturized biosensor devices.
- Review of existing literature on microfluidic biosensor technologies.
Main Results:
- Microfluidic biosensors demonstrate advantages in mobility, stability, and small reaction volumes.
- These devices offer potential for sensitive analyte detection in limited sample volumes.
- The review critically examines the development and application pathways for microfluidic biosensors.
Conclusions:
- Microfluidic technology is key to overcoming limitations of conventional biosensors.
- Further development is needed to fully realize the potential of miniaturized biosensors for point-of-care diagnostics.
- The integration of microfluidics enables more efficient and versatile biosensing platforms.
