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Author Spotlight: Understanding Cytokine-Induced Cell Death in Intestinal Epithelial Cells Using Human Organoids
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Author Spotlight: Understanding Cytokine-Induced Cell Death in Intestinal Epithelial Cells Using Human Organoids

Published on: August 2, 2024

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Non-Canonical Programmed Cell Death in Colon Cancer

Bingchen Pan1, Bowen Zheng1, Chengzhong Xing1

  • 1Department of Anus and Intestine Surgery, First Affiliated Hospital of China Medical University, Shenyang 110001, China.

Cancers
|July 27, 2022
PubMed

Insights

Programmed cell death (PCD) encompasses various cell suicide pathways. This review explores how non-canonical PCD types influence colon cancer development, treatment, and drug resistance.

Area of Science:

  • Oncology
  • Cell Biology
  • Molecular Biology

Background:

  • Programmed cell death (PCD) is a fundamental biological process crucial for development and tissue homeostasis.
  • Non-canonical PCD pathways, distinct from apoptosis, are increasingly recognized for their roles in disease.
  • Colon cancer remains a significant global health challenge, driven by complex genetic and environmental factors.

Purpose of the Study:

  • To systematically review the involvement of diverse non-canonical programmed cell death (PCD) modalities in colon cancer.
  • To elucidate the association between non-canonical PCD and colon cancer initiation, progression, prevention, and prognosis.
  • To explore the therapeutic potential of targeting non-canonical PCD in drug-resistant colon cancer.

Main Methods:

  • Comprehensive literature review of studies investigating non-canonical PCD in colon cancer.
  • Analysis of signaling pathways and molecular mechanisms underlying various non-canonical PCD types (e.g., ferroptosis, pyroptosis, necroptosis).
  • Synthesis of evidence on the interplay between different non-canonical PCD pathways and their collective impact on colon cancer.

Main Results:

  • Multiple non-canonical PCD types, including ferroptosis, pyroptosis, necroptosis, and others, are implicated in colon cancer pathogenesis.
  • These pathways influence tumor initiation, growth, metastasis, and response to therapy.
  • Interactions among different non-canonical PCD pathways modulate colon cancer progression and drug resistance.

Conclusions:

  • Non-canonical PCD pathways represent promising therapeutic targets for colon cancer treatment.
  • Understanding the complex interactions of these pathways is critical for developing effective anti-cancer strategies.
  • Targeting non-canonical PCD offers a potential avenue for overcoming drug resistance in colon cancer.
Keywords:
carcinogenesiscell deathcolon cancer

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