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Dietary Patterns and Prostate Cancer: CAPLIFE Study
Macarena Lozano-Lorca1,2, Margarita Rodríguez-González3, Inmaculada Salcedo-Bellido2,3,4
1Departamento de Enfermería, Facultad de Ciencias de la Salud de Ceuta, Universidad de Granada, 51001 Ceuta, Spain.
Cancers
|July 27, 2022
Summary
An unhealthy diet is linked to increased prostate cancer (PCa) risk, particularly for localized tumors with lower aggressiveness (ISUP 1-2). This finding highlights the importance of dietary patterns in prostate cancer development.
Area of Science:
- Oncology
- Nutritional Epidemiology
- Public Health
Background:
- The exact causes of prostate cancer (PCa) are not fully understood.
- The influence of dietary habits on PCa development requires further investigation.
Purpose of the Study:
- To examine the association between distinct dietary patterns and the risk of prostate cancer.
- To consider the impact of diet on tumor aggressiveness and extent in prostate cancer cases.
Main Methods:
- The CAPLIFE study utilized a population-based case-control design.
- Dietary intake was assessed using a validated food frequency questionnaire.
- Principal component analysis identified three dietary patterns: Mediterranean, Western, and Unhealthy. Logistic regression analyzed associations with PCa risk.
Main Results:
- High adherence to an unhealthy dietary pattern was associated with increased odds of prostate cancer (OR T3vsT1 = 1.52).
- This association was particularly evident in cases with International Society of Urological Pathology (ISUP) grade group 1-2 and localized tumors.
- No significant association was found between Western or Mediterranean dietary patterns and prostate cancer risk.
Conclusions:
- Adherence to an unhealthy diet may elevate the risk of developing prostate cancer.
- The association appears stronger for localized prostate cancer with lower tumor aggressiveness (ISUP 1-2).
- Further research into dietary interventions for prostate cancer prevention is warranted.
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