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MicroRNAs, Tristetraprolin Family Members and HuR: A Complex Interplay Controlling Cancer-Related Processes

Cyril Sobolewski1, Laurent Dubuquoy1, Noémie Legrand1

  • 1Inserm, CHU Lille, U1286-INFINITE-Institute for Translational Research in Inflammation, Univ. Lille, F-59000 Lille, France.

Cancers
|July 27, 2022
PubMed

Insights

MicroRNAs (miRNAs) regulate gene expression and are implicated in diseases. This review explores the complex interplay between miRNAs and RNA-binding proteins, crucial for developing new therapies.

Area of Science:

  • Molecular Biology
  • Gene Regulation
  • Disease Mechanisms

Background:

  • MicroRNAs (miRNAs) are key post-transcriptional regulators of gene expression.
  • Altered miRNA expression is linked to metabolic diseases, inflammatory conditions, and cancers.
  • Current therapeutic strategies focus on modulating miRNA expression for disease treatment.

Purpose of the Study:

  • To review the complex interplay between miRNAs and AU-Rich Element Binding Proteins (AUBPs).
  • To highlight the roles of HuR, TTP, BRF1, and BRF2 in mRNA fate and disease.
  • To emphasize the challenge in understanding these interactions for therapeutic development.

Main Methods:

  • Literature review of studies on miRNA and AUBP interactions.
  • Analysis of the functional consequences of these interactions in disease.
  • Synthesis of current knowledge on post-transcriptional regulation.

Main Results:

  • miRNA function is influenced by competing or cooperating trans-acting factors like long-noncoding RNAs and RNA-Binding Proteins.
  • AUBPs, including HuR and tristetraprolin family members (TTP, BRF1, BRF2), control mRNA fate.
  • Dysregulation of both miRNAs and AUBPs is associated with chronic disorders and cancers.

Conclusions:

  • The regulatory network involving miRNAs and AUBPs is more complex than previously thought.
  • Understanding the interplay between miRNAs and AUBPs is critical for characterizing pro-tumorigenic processes.
  • Deciphering these interactions is essential for designing effective therapeutic strategies.
Keywords:
AUBPHuRTTPcancersmicroRNAs

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