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3D Bioprinting: An Enabling Technology to Understand Melanoma
Samantha Fernandes1, Cian Vyas1,2, Peggy Lim1
1Department of Mechanical, Aerospace and Civil Engineering, University of Manchester, Oxford Road, Manchester M13 9PL, UK.
Cancers
|July 27, 2022
Summary
Melanoma, a dangerous skin cancer, is increasing globally. New 3D bioprinted skin models offer a promising way to better understand melanoma and test new treatments.
Area of Science:
- Oncology
- Dermatology
- Biofabrication
Background:
- Melanoma incidence has risen significantly over 50 years, linked to UV exposure.
- Risk factors include age, ethnicity, UV exposure, and anatomic site.
- Advances in therapies improve survival, but deeper biological understanding is crucial.
Purpose of the Study:
- To explore the potential of 3D human skin equivalent models for melanoma research.
- To investigate biofabrication techniques, like bioprinting, for creating these models.
- To establish a platform for understanding melanoma complexity and testing therapeutics.
Main Methods:
- Development of three-dimensional (3D) human skin equivalent models.
- Utilizing biofabrication techniques, including bioprinting.
- Establishing a platform for melanoma research and therapeutic testing.
Main Results:
- 3D skin models show promise for understanding melanoma biology.
- Bioprinting offers a viable method for creating complex skin models.
- These models can serve as a basis for patient-specific research and drug screening.
Conclusions:
- 3D bioprinted skin models represent a significant advancement in melanoma research.
- These models facilitate a better understanding of melanoma development and risk factors.
- They offer a novel platform for personalized medicine and therapeutic development in melanoma treatment.
