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Updated: Sep 3, 2025

In Vivo Immunogenicity Screening of Tumor-Derived Extracellular Vesicles by Flow Cytometry of Splenic T Cells
Published on: September 23, 2021
Effects of Exosomal Viral Components on the Tumor Microenvironment
Jing Li1, Yan Zhang1,2, Bing Luo1
1Department of Pathogenic Biology, School of Basic Medicine, Qingdao University, Qingdao 266071, China.
Abstract:
Exosomes are extracellular membrane vesicles with a diameter of 30-100 nm, produced by different eukaryotic cells that contain multitudinous lipids, nucleic acids, and proteins. They transfer membrane components and nucleic acids between cells, thereby performing an information exchange between cells. Many studies have shown that a variety of tumor-associated viruses can exert their biological functions through exosomes. The tumor microenvironment (TME) is very important in the occurrence, development, and chemoresistance of tumors. It is composed of tumor cells, fibroblasts, endothelial cells, immune cells, stromal cells, and acellular components, such as exosomes and cytokines. This review focuses on the effects of virus-related components secreted by tumor cells over the TME in several virus-associated cancers.
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