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3D Printed Hydrogels for Ocular Wound Healing.
Mohamadreza Aghamirsalim1, Mohammadmahdi Mobaraki2, Madjid Soltani3,4,5,6
1Translational Ophthalmology Research Center, Tehran University of Medical Science, Tehran 14176-14411, Iran.
Biomedicines
|July 27, 2022
Summary
Hydrogels show promise as bioinks for 3D bioprinting artificial corneas, addressing the critical shortage of donor corneas for transplantation and combating corneal blindness.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Ophthalmology
Background:
- Corneal disease is a leading cause of global blindness, with transplantation being the primary treatment.
- A significant shortage of donor corneas exists, creating a critical need for alternative solutions.
- Traditional methods for fabricating artificial corneas face challenges due to their unique optical and structural properties.
Purpose of the Study:
- To review the application of hydrogels as bioinks for corneal tissue engineering.
- To explore various bioprinting methods suitable for corneal regeneration.
- To discuss the properties and types of hydrogels relevant for corneal bioprinting.
Main Methods:
- Review of scientific literature on hydrogels, bioprinting, and corneal tissue engineering.
- Analysis of hydrogel properties relevant to corneal scaffold fabrication.
- Examination of different bioprinting techniques for creating corneal structures.
Main Results:
- Hydrogels possess unique properties making them suitable bioinks for corneal tissue engineering.
- 3D bioprinting offers a viable approach to overcome limitations in fabricating complex corneal structures.
- Various hydrogel types and bioprinting strategies are being investigated for corneal regeneration.
Conclusions:
- Hydrogels are promising biomaterials for developing bioinks in 3D bioprinting of corneal scaffolds.
- Bioprinting technologies, utilizing hydrogels, present a potential solution to the donor cornea shortage.
- Further research into hydrogel-based bioprinting is crucial for advancing corneal regenerative medicine.
