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Spinal Cord Injury ll: Pathophysiology

Spinal Cord Injury ll: Pathophysiology

Spinal cord injury progresses through two interconnected phases: primary injury and secondary injury.Primary InjuryPrimary injury happens at the moment of trauma and involves immediate mechanical damage to the spinal cord.Compression happens when broken vertebrae, herniated discs, or accumulating blood (such as a hematoma) press directly against the spinal cord, distorting its normal shape and function. In cases of contusion, the cord is bruised by a blunt force (like penetrating injuries or...

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Promotion of Survival and Differentiation of Neural Stem Cells with Fibrin and Growth Factor Cocktails after Severe Spinal Cord Injury

Promotion of Survival and Differentiation of Neural Stem Cells with Fibrin and Growth Factor Cocktails after Severe Spinal Cord Injury

Published on: July 27, 2014

Biomaterial-Mediated Factor Delivery for Spinal Cord Injury Treatment.

Filippo Pinelli¹, Fabio Pizzetti¹, Valeria Veneruso²

¹Department of Chemistry, Materials and Chemical Engineering "Giulio Natta", Politecnico di Milano, Via Mancinelli 7, 20131 Milan, Italy.

|July 27, 2022

Summary

Spinal cord injury (SCI) treatment requires addressing multiple factors due to its complex, multifactorial nature. Combinatorial strategies using biomaterials offer a promising multitarget approach for neural regeneration and recovery.

Keywords:

hydrogels inflammation nanoparticles regeneration spinal cord

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Published on: November 3, 2017

Area of Science:

Neuroscience
Regenerative Medicine
Biomaterials Science

Background:

Spinal cord injury (SCI) involves acute trauma followed by progressive tissue damage in the subacute phase, leading to neural degeneration.
Existing therapeutic interventions for SCI have shown limited clinical success due to the multifactorial nature of the injury.
Addressing only single pathological factors is insufficient to halt neural degeneration and paralysis post-SCI.

Purpose of the Study:

To review current single and combinatorial regenerative treatments for spinal cord injury.
To explore potential biomaterial-based delivery options for multitargeted SCI therapies.
To highlight the need for comprehensive strategies in managing SCI pathogenesis.

Main Methods:

Literature review of single-factor and combinatorial regenerative treatments for SCI.
Analysis of biomaterial applications for in situ drug/biomolecule delivery.
Examination of therapeutic approaches targeting multiple neurodegenerative mechanisms.

Main Results:

Single-factor treatments have yielded limited success in clinical settings for SCI.
Combinatorial strategies utilizing biomaterials show potential for maximized multitargeting.
Various regenerative factors and delivery systems are being investigated for SCI treatment.

Conclusions:

Effective SCI treatment necessitates a multitargeted approach addressing the multifactorial pathogenesis.
Biomaterial-based combinatorial therapies represent a promising avenue for enhancing neural regeneration.
Further research into optimized delivery systems is crucial for advancing SCI clinical outcomes.