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Related Concept Videos

Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

302
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
302
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

367
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
367
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

534
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
534
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF01:24

Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF

224
Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
224
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

401
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
401
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents01:29

Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents

259
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
259

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Chronic Salmonella Infection Induced Intestinal Fibrosis
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RNA Modification in Inflammatory Bowel Diseases.

Mika Nakayama1, Yuki Ozato1,2, Yoshiko Tsuji1

  • 1Department of Medical Data Science, Center of Medical Innovation and Translational Research, Graduate School of Medicine, Osaka University, Suita 565-0871, Japan.

Biomedicines
|July 27, 2022
PubMed
Summary
This summary is machine-generated.

RNA modifications are increasingly recognized for their role in inflammatory bowel disease (IBD) pathogenesis. Targeting these RNA changes offers potential for early diagnosis and novel therapeutic strategies for IBD.

Keywords:
RNA modificationinflammatory bowel disease

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Area of Science:

  • Gastroenterology
  • Molecular Biology
  • Immunology

Background:

  • Inflammatory bowel disease (IBD) is a chronic condition damaging the intestinal lining.
  • IBD involves genetic, environmental, microbial, and immune factors, sometimes leading to cancer.
  • Emerging research highlights RNA modifications' role in IBD's molecular mechanisms.

Purpose of the Study:

  • To review the involvement of RNA modifications in IBD pathogenesis.
  • To discuss the potential of targeting RNA modifications for IBD diagnosis and treatment.

Main Methods:

  • Literature review of recent studies on RNA modifications and IBD.
  • Analysis of RNA modification's impact on epithelial and immune cells in IBD.

Main Results:

  • RNA modifications regulate RNA biology in IBD pathogenesis.
  • RNA modification-targeting agents show promise in colitis models.
  • A growing understanding of RNA modification's role in IBD and related conditions.

Conclusions:

  • RNA modifications are critical in IBD development.
  • Targeting RNA modifications presents new avenues for IBD diagnosis and therapy.
  • Further research into RNA modification offers innovative therapeutic approaches for IBD.