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Automated Robotic Liquid Handling Assembly of Modular DNA Devices
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Formalising the Pathways to Life Using Assembly Spaces.

Stuart M Marshall1, Douglas G Moore2, Alastair R G Murray1

  • 1School of Chemistry, University of Glasgow, Glasgow G12 8QQ, UK.

Entropy (Basel, Switzerland)
|July 27, 2022
PubMed
Summary
This summary is machine-generated.

Assembly theory quantifies the information needed to build objects, defining a new scale of aliveness. Objects with high assembly index indicate directed biological or technological origins, distinguishing them from random processes.

Keywords:
biosignaturescomplexitygraphsinformation

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Area of Science:

  • Complexity Science
  • Origin of Life Studies
  • Biophysics

Background:

  • Assembly theory, previously pathway assembly, quantifies extrinsic information to distinguish objects from random ensembles.
  • Prior work explored deconstructing objects into irreducible parts and rebuilding them, allowing sub-object reuse.
  • The approach has been applied to molecular assembly for experimental inference and life detection.

Purpose of the Study:

  • Formalize core assembly concepts mathematically using assembly spaces.
  • Determine bounds on the assembly index.
  • Propose a new scale of aliveness based on assembly index to identify life.

Main Methods:

  • Mathematical formalization of assembly concepts into assembly spaces.
  • Analysis of assembly spaces for mathematical and physical objects.
  • Determination of bounds for the assembly index.

Main Results:

  • Objects with high assembly index are uniquely identifiable as products of directed processes.
  • A new scale of aliveness is proposed based on the assembly index.
  • The study provides a framework for quantifying life's processes.

Conclusions:

  • Assembly theory offers a quantitative approach to understanding life.
  • High assembly index objects suggest non-random, directed origins (biological or technological).
  • This framework aids in identifying physical and chemical laws governing life by quantifying its actions.