Related Experiment Video
Updated: Sep 3, 2025

Expression, Purification, and Antimicrobial Activity of S100A12
Published on: May 13, 2017
Influence of S100A2 in Human Diseases
1Department of Dermatology, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan.
Abstract:
S100 proteins are a family of low-molecular-weight proteins characterized by two calcium-binding sites with a helix-loop-helix ("EF-hand-type") domain. The S100 family of proteins is distributed across various organs and can interact with diverse molecules. Among the proteins of the S100 family, S100 calcium-binding protein A2 (S100A2) has been identified in mammary epithelial cells, glands, lungs, kidneys, and prostate gland, exhibiting various physiological and pathological actions in human disorders, such as inflammatory diseases and malignant tumors. In this review, we introduce basic knowledge regarding S100A2 regulatory mechanisms. Although S100A2 is a tumor suppressor, we describe the various influences of S100A2 on cancer and inflammatory diseases.
Related Concept Videos
Pleiotropy
NF-κB-dependent Signaling Pathway
NF-κB-dependent Signaling Mechanism
The...

