Screening Lung Diseases Using Cascaded Feature Generation and Selection Strategies

The global pandemic COVID-19 is still a cause of a health emergency in several parts of the world. Apart from standard testing techniques to identify positive cases, auxiliary tools based on artificial intelligence can help with the identification and containment of the disease. The need for the development of alternative smart diagnostic tools to combat the COVID-19 pandemic has become more urgent. In this study, a smart auxiliary framework based on machine learning (ML) is proposed; it can help medical practitioners in the identification of COVID-19-affected patients, among others with pneumonia and healthy individuals, and can help in monitoring the status of COVID-19 cases using X-ray images. We investigated the application of transfer-learning (TL) networks and various feature-selection techniques for improving the classification accuracy of ML classifiers. Three different TL networks were tested to generate relevant features from images; these TL networks include AlexNet, ResNet101, and SqueezeNet. The generated relevant features were further refined by applying feature-selection methods that include iterative neighborhood component analysis (iNCA), iterative chi-square (iChi2), and iterative maximum relevance-minimum redundancy (iMRMR). Finally, classification was performed using convolutional neural network (CNN), linear discriminant analysis (LDA), and support vector machine (SVM) classifiers. Moreover, the study exploited stationary wavelet (SW) transform to handle the overfitting problem by decomposing each image in the training set up to three levels. Furthermore, it enhanced the dataset, using various operations as data-augmentation techniques, including random rotation, translation, and shear operations. The analysis revealed that the combination of AlexNet, ResNet101, SqueezeNet, iChi2, and SVM was very effective in the classification of X-ray images, producing a classification accuracy of 99.2%. Similarly, AlexNet, ResNet101, and SqueezeNet, along with iChi2 and the proposed CNN network, yielded 99.0% accuracy. The results showed that the cascaded feature generator and selection strategies significantly affected the performance accuracy of the classifier.