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Published on: May 21, 2019
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The Epitranscriptome in miRNAs: Crosstalk, Detection, and Function in Cancer.
Daniel Del Valle-Morales1, Patricia Le1, Michela Saviana1
1Division of Pulmonary Diseases and Critical Care Medicine, Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA.
Genes
|July 27, 2022
Summary
The epitranscriptome, RNA modifications, impacts gene regulation and disease. This review details microRNA (miRNA) epitranscriptomic modifications and their complex crosstalk.
Area of Science:
- Molecular Biology
- Epigenetics
- RNA Biology
Background:
- The epitranscriptome comprises RNA post-transcriptional modifications influencing RNA function and regulation.
- Dysregulated RNA modifications are linked to diseases and cancers.
- MicroRNAs (miRNAs) are key regulators of gene expression with significant clinical relevance.
Purpose of the Study:
- To review epitranscriptomic modifications affecting miRNAs.
- To examine the crosstalk between these miRNA modifications.
- To explore how this crosstalk enhances miRNA biology complexity.
Main Methods:
- Literature review focusing on epitranscriptomic modifications of miRNAs.
- Analysis of emerging studies on the crosstalk between these modifications.
- Synthesis of current knowledge and future perspectives.
Main Results:
- miRNAs undergo various epitranscriptomic modifications (m 6 A, 2'-O-methylation, m 5 C, m 7 G, polyuridine, A-to-I editing).
- These modifications impact miRNA targeting, regulation, and biogenesis.
- Evidence suggests significant crosstalk between different epitranscriptomic modifications on miRNAs.
Conclusions:
- Epitranscriptomic modifications add layers of complexity to miRNA-mediated gene regulation.
- The crosstalk between miRNA modifications further expands this regulatory complexity.
- Understanding these modifications and their interactions is crucial for disease and cancer research.
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