Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Actions of adenosine on the sinus node.

G A West

    Progress in Clinical and Biological Research
    |January 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Adenosine slows heart rate by affecting pacemaker cells directly via A1 receptors. This mechanism, involving hyperpolarization and K+ channels, is crucial for understanding and potentially treating bradyarrhythmias.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Development of nuclease activity in cotyledons of Pisum sativum L.

    Planta·2014
    Same author

    Iso-enzymes of acid ribonuclease in cotyledons of Pisum sativum L.

    Planta·2014
    Same author

    Gaseous trace analysis using pulsed photoacoustic Raman spectroscopy.

    Applied optics·2010
    Same author

    Pure rotational stimulated Raman photoacoustic spectroscopy.

    Optics letters·2009
    Same author

    Perioperative complications with costotransversectomy and anterior approaches to thoracic and thoracolumbar tumors.

    Neurosurgical focus·2006
    Same author

    Divergent cell cycle kinetics underlie the distinct functional capacity of mucosal T cells in Crohn's disease and ulcerative colitis.

    Gut·2004

    Area of Science:

    • Cardiology
    • Electrophysiology
    • Pharmacology

    Background:

    • Adenosine exerts a negative chronotropic effect on cardiac pacemaker tissue.
    • This effect is mediated by extracellular adenosine receptors, specifically the A1 subtype.
    • Adenosine influences pacemaker cell function and can cause shifts in the heart's pacemaker site.

    Purpose of the Study:

    • To elucidate the mechanism by which adenosine affects pacemaker cells.
    • To investigate the role of adenosine receptors in mediating cardiac chronotropy.
    • To explore the potential clinical relevance of adenosine in bradyarrhythmias.

    Main Methods:

    • Investigated the direct effects of adenosine on pacemaker cells.
    • Examined the role of extracellular adenosine receptors (A1 subtype).

    Related Experiment Videos

  • Assessed the impact of adenosine on membrane potential and depolarization phases.

    • Main Results:

    • Adenosine causes hyperpolarization of pacemaker cell membranes, decreasing phase 4 depolarization.
    • This effect is attributed to an adenosine-activated potassium (K+) conductance.
    • Adenosine exhibits a hierarchical sensitivity among pacemakers, with the His bundle being most sensitive.
    • Adenosine and acetylcholine effects are additive, suggesting potential shared K+ channel activation.

    Conclusions:

    • Adenosine directly slows heart rate by hyperpolarizing pacemaker cells via A1 receptors and K+ channels.
    • Adenosine's effects are similar to acetylcholine, indicating potential convergence on ion channel pathways.
    • Adenosine plays a significant role in modulating bradyarrhythmias and warrants further molecular investigation.