Related Experiment Video

Updated: Sep 3, 2025

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
07:29

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

9.4K

Effect of Low High-Density Lipoprotein Level on Endothelial Activation and Prothrombotic Processes in Coronary Artery

Magdalena Lampka1, Dorota Olszewska-Słonina1, Iga Hołyńska-Iwan1

  • 1Department of Pathobiochemistry and Clinical Chemistry, Faculty of Pharmacy, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, 87-100 Toruń, Poland.

International Journal of Environmental Research and Public Health
|July 27, 2022
PubMed

Insights

Low high-density lipoprotein cholesterol (HDL-C) in coronary artery disease (CAD) patients is linked to increased inflammation and clotting. A low HDL-C and high LDL-C/HDL-C ratio better indicate atherosclerosis than LDL-C alone.

Area of Science:

  • Cardiovascular Medicine
  • Biochemistry
  • Atherosclerosis Research

Background:

  • High-density lipoproteins (HDL) are crucial in preventing atherosclerosis.
  • Coronary artery disease (CAD) involves complex inflammatory and thrombotic processes.
  • Understanding the role of HDL-C in these processes is vital for patient outcomes.

Purpose of the Study:

  • To investigate the association between serum HDL-C levels and markers of proinflammatory and prothrombotic activation in CAD patients.
  • To compare these markers in patients with acute myocardial infarction (AMI) and stable angina pectoris (SA) against a control group.

Main Methods:

  • Serum HDL-C, LDL-C, triglycerides, and other biomarkers (sE-selectin ligand, CD40, von Willebrand Factor, intercellular adhesion molecule-1) were measured.
  • Patients were categorized into AMI, SA, and control groups.
  • Statistical analysis was performed to compare biomarker levels across groups.

Main Results:

  • Patients with CAD (AMI and SA) exhibited lower HDL-C and a higher LDL-C/HDL-C index compared to controls.
  • SA patients showed lower total cholesterol, LDL-C, and sE-selectin ligand, but higher triglycerides and CD40 than controls and AMI patients.
  • Elevated von Willebrand Factor and intercellular adhesion molecule-1 were observed in both CAD groups.

Conclusions:

  • Low HDL-C concentration in CAD patients may exacerbate pro-inflammatory endothelial activation and prothrombotic tendencies.
  • The LDL-C/HDL-C ratio and HDL-C levels appear to be more sensitive indicators of atherogenic processes than LDL-C alone.

Keywords:
coronary artery diseasehigh-density lipoproteinsCD40LsE-selectinsICAM-1von Willebrand factor

More Related Videos

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles09:15

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Published on: November 10, 2017

14.7K
Using En Face Immunofluorescence Staining to Observe Vascular Endothelial Cells Directly06:09

Using En Face Immunofluorescence Staining to Observe Vascular Endothelial Cells Directly

Published on: August 20, 2019

15.6K

Related Concept Videos

Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
31
Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
31
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
51
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
71
Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
290
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
29