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Updated: Sep 3, 2025

Visualization of HIV-1 Gag Binding to Giant Unilamellar Vesicle GUV Membranes
Published on: July 28, 2016
The HIV-1 Gag Protein Displays Extensive Functional and Structural Roles in Virus Replication and Infectivity
Veronna Marie1, Michelle Lucille Gordon1
1KwaZulu-Natal Research, Innovation and Sequencing Platform, University of KwaZulu-Natal, Durban 4041, South Africa.
Abstract:
Once merely thought of as the protein responsible for the overall physical nature of the human immunodeficiency virus type 1 (HIV-1), the Gag polyprotein has since been elucidated to have several roles in viral replication and functionality. Over the years, extensive research into the polyproteins' structure has revealed that Gag can mediate its own trafficking to the plasma membrane, it can interact with several host factors and can even aid in viral genome packaging. Not surprisingly, Gag has also been associated with HIV-1 drug resistance and even treatment failure. Therefore, this review provides an extensive overview of the structural and functional roles of the HIV-1 Gag domains in virion integrity, functionality and infectivity.
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