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Updated: Sep 3, 2025

Controllable Ion Channel Expression through Inducible Transient Transfection
Published on: February 17, 2017
New Insights into TRP Ion Channels in Stem Cells
Jing Guo1, Chang Shan1, Jiao Xu1
1Institute of Cancer Stem Cell, Dalian Medical University, Dalian 116044, China.
Abstract:
Transient receptor potential (TRP) ion channels are cationic permeable proteins located on the plasma membrane. TRPs are cellular sensors for perceiving diverse physical and/or chemical stimuli; thus, serving various critical physiological functions, including chemo-sensation, hearing, homeostasis, mechano-sensation, pain, taste, thermoregulation, vision, and even carcinogenesis. Dysregulated TRPs are found to be linked to many human hereditary diseases. Recent studies indicate that TRP ion channels are not only involved in sensory functions but are also implicated in regulating the biological characteristics of stem cells. In the present review, we summarize the expressions and functions of TRP ion channels in stem cells, including cancer stem cells. It offers an overview of the current understanding of TRP ion channels in stem cells.
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