Related Experiment Video
Updated: Sep 3, 2025

Intraspinal Cell Transplantation for Targeting Cervical Ventral Horn in Amyotrophic Lateral Sclerosis and Traumatic Spinal Cord Injury
Published on: September 18, 2011
The Role and Therapeutic Potential of the Integrated Stress Response in Amyotrophic Lateral Sclerosis
Elías Marlin1,2,3,4, Cristina Viu-Idocin5, Montserrat Arrasate1,3,4
1Neuroscience Program, Center for Applied Medical Research (CIMA), University of Navarra, 31008 Pamplona, Spain.
Abstract:
In amyotrophic lateral sclerosis (ALS) patients, loss of cellular homeostasis within cortical and spinal cord motor neurons triggers the activation of the integrated stress response (ISR), an intracellular signaling pathway that remodels translation and promotes a gene expression program aimed at coping with stress. Beyond its neuroprotective role, under regimes of chronic or excessive stress, ISR can also promote cell/neuronal death. Given the two-edged sword nature of ISR, many experimental attempts have tried to establish the therapeutic potential of ISR enhancement or inhibition in ALS. This review discusses the complex interplay between ISR and disease progression in different models of ALS, as well as the opportunities and limitations of ISR modulation in the hard quest to find an effective therapy for ALS.
Related Concept Videos
Role of Amygdala in Memory
One of the...
Physiological Foundation of Stress
Role of the Sympathetic Nervous System
Adrenaline triggers the...
Hypothalamic-Pituitary Axis
Introduction to Stress and Lifestyle
Psychological Responses to Stress
Stress Response System
Alarm stage
In the alarm stage, the body's...

