Related Experiment Video

Updated: Sep 3, 2025

Author Spotlight: Advancements in Stem Cell Regenerative Therapy Through Photobiomodulation
05:42

Author Spotlight: Advancements in Stem Cell Regenerative Therapy Through Photobiomodulation

Published on: April 5, 2024

1.1K

Therapeutic Potential of Photobiomodulation for Chronic Kidney Disease

Ji Bian1, Ann Liebert2,3, Brian Bicknell3

  • 1Kolling Institute, Sydney Medical School, Faculty of Medicine and Health, University of Sydney, Royal North Shore Hospital, St Leonards, NSW 2065, Australia.

International Journal of Molecular Sciences
|July 27, 2022
PubMed

Insights

Photobiomodulation (PBM) therapy shows promise for chronic kidney disease (CKD) by addressing key disease mechanisms. This non-invasive light treatment may offer a novel therapeutic avenue for CKD patients.

Area of Science:

  • Nephrology
  • Biomedical Engineering
  • Light Therapy

Background:

  • Chronic kidney disease (CKD) is a significant global health issue.
  • Current interventions for CKD only delay kidney failure, highlighting the need for innovative treatments.
  • CKD involves mitochondrial dysfunction, oxidative stress, inflammation, and gut dysbiosis.

Purpose of the Study:

  • To review the mechanisms of action for photobiomodulation (PBM).
  • To explore the potential therapeutic effects of PBM on chronic kidney disease (CKD).
  • To assess PBM as a novel treatment for CKD.

Main Methods:

  • Literature review of photobiomodulation (PBM) mechanisms.
  • Analysis of PBM's effects on CKD-associated pathologies.
  • Synthesis of preliminary studies on PBM in kidney disease.

Main Results:

  • PBM effectively mitigates mitochondrial dysfunction, oxidative stress, inflammation, and gut microbiota dysbiosis.
  • Preliminary evidence suggests PBM benefits in various diseases, including CKD.
  • PBM's action mechanisms align with key pathological processes in CKD.

Conclusions:

  • Photobiomodulation (PBM) presents a potential non-invasive, non-pharmacological therapeutic strategy for CKD.
  • Further research is required to validate PBM's efficacy and safety before widespread clinical recommendation.
  • PBM may offer a novel approach to managing chronic kidney disease.
Keywords:
chronic kidney diseasegut microbiota dysbiosisinflammationmitochondrial dysfunctionoxidative stressphotobiomodulation

More Related Videos

Author Spotlight: Developing Photo-Stimulation Technology for Toxin Removal in Sleep-Related Brain Diseases07:56

Author Spotlight: Developing Photo-Stimulation Technology for Toxin Removal in Sleep-Related Brain Diseases

Published on: June 28, 2024

876
5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats05:34

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

807

Related Concept Videos

Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
76
Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
62
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
76
Chronic Kidney Disease IV: Nursing Management01:18

Chronic Kidney Disease IV: Nursing Management

Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care​.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of...
50
Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
66
Acute Kidney Injury V: Interprofessional Care01:20

Acute Kidney Injury V: Interprofessional Care

Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
44