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Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis
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Aspergillus Endophthalmitis: Epidemiology, Pathobiology, and Current Treatments

Alisha Khambati1, Robert Emery Wright1, Susmita Das1

  • 1Department of Ophthalmology, Visual and Anatomical Sciences, School of Medicine, Wayne State University, Detroit, MI 48201, USA.

Journal of Fungi (Basel, Switzerland)
|July 27, 2022
PubMed

Insights

Fungal endophthalmitis, often caused by Aspergillus, leads to vision loss. Understanding its transmission, immune response, and diagnosis is key for effective antifungal treatments and surgical interventions.

Area of Science:

  • Ophthalmology
  • Mycology
  • Infectious Diseases

Background:

  • Fungal endophthalmitis is a significant cause of global vision loss, frequently linked to post-operative or traumatic ocular injuries.
  • Immunocompromised individuals are particularly susceptible to fungal keratitis, with Aspergillus species, especially Aspergillus fumigatus, being a prevalent pathogen.
  • The overlapping clinical presentation with other endophthalmitis types complicates diagnosis and treatment, necessitating a deeper understanding of its pathobiology.

Purpose of the Study:

  • To review the transmission routes of Aspergillus in endophthalmitis.
  • To elucidate the host immune response during fungal endophthalmitis.
  • To summarize current diagnostic advancements and therapeutic strategies for Aspergillus endophthalmitis.

Main Methods:

  • Literature review focusing on fungal endophthalmitis, particularly Aspergillus.
  • Analysis of transmission pathways and host-pathogen interactions.
  • Synthesis of recent findings on diagnostic techniques and treatment options.

Main Results:

  • Aspergillus species are a leading cause of fungal endophthalmitis, posing diagnostic and therapeutic challenges.
  • Understanding transmission and immune response is crucial for developing targeted interventions.
  • Recent diagnostic tools and a range of antifungal and surgical treatments are available.

Conclusions:

  • Effective management of Aspergillus endophthalmitis requires a comprehensive approach.
  • Continued research into diagnosis and treatment is vital to mitigate vision loss.
  • This review provides a consolidated overview of current knowledge and therapeutic options.
Keywords:
Aspergillusantifungaldiagnosisfungal endophthalmitispathogenesis

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