Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

5.1K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.1K
Improving Translational Accuracy02:07

Improving Translational Accuracy

11.8K
Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...
11.8K
Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

297
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
297
Translation01:31

Translation

15.3K
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
Proteins are...
15.3K
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

168
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
168

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparing National Health Technology Assessment approaches and the new European Joint Clinical Assessment framework: The case of onco-hematological medicines.

European journal of clinical pharmacology·2026
Same author

Correction: Manifesto of the collaborative alliance for research and educationin surgery: the CARES network. "Surgical research must become amilestone of progress in patient care in Italy".

Updates in surgery·2026
Same author

Nonoperative Management of Uncomplicated Acute Appendicitis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials Comparing Antibiotic Treatment and Appendectomy in Children and Adolescents.

World journal of surgery·2026
Same author

Pharmacological interventions for the treatment of obesity in children and adolescents.

The Cochrane database of systematic reviews·2026
Same author

Impact of Weight Bias, Stigma and Discrimination on Physical, Mental, and Quality of Life Outcomes of Metabolic and Bariatric Surgery: A Systematic Review.

Obesity surgery·2026
Same author

An international consensus on core reproducibility items in research.

PLoS biology·2026
Same journal

RETRACTED: Zito Marino et al. AXL and MET Tyrosine Kinase Receptors Co-Expression as a Potential Therapeutic Target in Malignant Pleural Mesothelioma. <i>J. Pers. Med.</i> 2022, <i>12</i>, 1993.

Journal of personalized medicine·2026
Same journal

Correction: Rao et al. Ensemble Deep-Learning-Based Prognostic and Prediction for Recurrence of Sporadic Odontogenic Keratocysts on Hematoxylin and Eosin Stained Pathological Images of Incisional Biopsies. <i>J. Pers. Med.</i> 2022, <i>12</i>, 1220.

Journal of personalized medicine·2026
Same journal

Three-Dimensional Bronchovascular Modelling in Sublobar Pulmonary Resection: A Tool for Personalised Thoracic Surgery.

Journal of personalized medicine·2026
Same journal

Serum Albumin, Globulin and Albumin-Globulin Ratios as Biomarkers of Clinical Outcomes in COVID-19 Pneumonia.

Journal of personalized medicine·2026
Same journal

New Advances and Perspectives in Ophthalmology: Progress and Modern Challenges Toward Personalized Eye Care.

Journal of personalized medicine·2026
Same journal

Bridging Ancestry-Stratified Bias in Pharmacogenomics AI: Toward Metabolomics-Inclusive Multi-Omics Precision Medicine.

Journal of personalized medicine·2026
See all related articles

Related Experiment Video

Updated: Sep 3, 2025

A Protocol for Using Gene Set Enrichment Analysis to Identify the Appropriate Animal Model for Translational Research
09:35

A Protocol for Using Gene Set Enrichment Analysis to Identify the Appropriate Animal Model for Translational Research

Published on: August 16, 2017

17.9K

Evaluating Translational Methods for Personalized Medicine-A Scoping Review.

Vibeke Fosse1, Emanuela Oldoni2, Chiara Gerardi3

  • 1Centre for Cancer Biomarkers, Department of Clinical Science, University of Bergen, 5021 Bergen, Norway.

Journal of Personalized Medicine
|July 27, 2022
PubMed
Summary
This summary is machine-generated.

Current preclinical models for personalized medicine, particularly in oncology and brain disorders, require significant development and validation. Addressing gaps in model relevance, quality, and translation is crucial for advancing predictive translational research.

Keywords:
personalized medicinepreclinical modelsstratified treatment selectiontranslational models

More Related Videos

Quantitative Immunofluorescence to Measure Global Localized Translation
09:13

Quantitative Immunofluorescence to Measure Global Localized Translation

Published on: August 22, 2017

10.0K
Author Spotlight: Cost-Effective Transcriptomic Drug Screening - Unlocking New Targets
06:40

Author Spotlight: Cost-Effective Transcriptomic Drug Screening - Unlocking New Targets

Published on: February 23, 2024

1.4K

Related Experiment Videos

Last Updated: Sep 3, 2025

A Protocol for Using Gene Set Enrichment Analysis to Identify the Appropriate Animal Model for Translational Research
09:35

A Protocol for Using Gene Set Enrichment Analysis to Identify the Appropriate Animal Model for Translational Research

Published on: August 16, 2017

17.9K
Quantitative Immunofluorescence to Measure Global Localized Translation
09:13

Quantitative Immunofluorescence to Measure Global Localized Translation

Published on: August 22, 2017

10.0K
Author Spotlight: Cost-Effective Transcriptomic Drug Screening - Unlocking New Targets
06:40

Author Spotlight: Cost-Effective Transcriptomic Drug Screening - Unlocking New Targets

Published on: February 23, 2024

1.4K

Area of Science:

  • Biomedical research
  • Translational medicine
  • Disease modeling

Background:

  • Personalized medicine relies on multi-omics data, presenting challenges for disease modeling.
  • Stratified medicine approaches require robust preclinical methodologies for evaluating treatment efficacy.

Purpose of the Study:

  • To evaluate the relevance, validity, and predictive value of current preclinical methodologies in personalized medicine.
  • To identify gaps and limitations in preclinical research for oncology and brain disorders.

Main Methods:

  • A scoping review following Joanna Briggs Institute guidelines.
  • Searched PubMed, EMBASE, and other databases for preclinical models in personalized medicine.
  • Quantitative and qualitative synthesis of 63 oncology and 94 brain disorder studies.

Main Results:

  • Existing preclinical models need further development and validation for personalized medicine.
  • Gaps identified in experimental model relevance, quality assessment, reporting, and regulation.
  • A significant gap exists between preclinical research and clinical application.

Conclusions:

  • Sophisticated biological systems are needed to assess integrated response mechanisms in personalized medicine.
  • Fundamental deficits in preclinical research must be addressed for effective implementation of predictive translational models.
  • Further validation and development of preclinical models are essential for realizing the potential of personalized medicine.