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Published on: November 28, 2018
Indicators of the Right Ventricle Systolic and Diastolic Function 18 Months after Coronary Bypass Surgery
Alexey N Sumin1, Anna V Shcheglova1, Ekaterina V Korok1
1Laboratory of Comorbidity in Cardiovascular Diseases, Department of Clinical Cardiology, Federal State Budgetary Scientific Institution "Research Institute for Complex Issues of Cardiovascular Disease", Sosnoviy Blvd., 6, 650002 Kemerovo, Russia.
Insights
Right ventricular dysfunction, both systolic and diastolic, significantly increased 18 months after coronary artery bypass grafting (CABG). Pre-existing RV dysfunction and specific echocardiographic measures were key predictors of post-CABG RV dysfunction.
Area of Science:
- Cardiology
- Cardiac Surgery
- Echocardiography
Background:
- Right ventricular (RV) dysfunction post-coronary artery bypass grafting (CABG) is linked to poor outcomes.
- Previous research primarily focused on RV systolic function, neglecting diastolic function dynamics after CABG.
Purpose of the Study:
- To investigate the changes in RV systolic and diastolic function indicators 18 months after CABG.
- To identify clinical and echocardiographic factors associated with RV dysfunction post-CABG.
Main Methods:
- 160 patients undergoing CABG and 36 controls were assessed.
- Echocardiography evaluated RV systolic and diastolic function before and 18 months after CABG.
- Specific echocardiographic parameters defined RV systolic and diastolic dysfunction.
Main Results:
- The incidence of RV systolic dysfunction rose from 7.5% to 30% (p < 0.001) and diastolic dysfunction from 41.8% to 57.5% (p < 0.001) 18 months post-CABG.
- Predictors for post-CABG RV systolic dysfunction included increased TAPSE, decreased e’t, and pre-existing RV systolic dysfunction.
- High pre-operative At values and prior myocardial infarction predicted RV diastolic dysfunction post-CABG.
Conclusions:
- Coronary artery bypass grafting is associated with a significant increase in both RV systolic and diastolic dysfunction 18 months post-surgery.
- Initial clinical and echocardiographic parameters, along with perioperative factors, are linked to the development of post-CABG RV dysfunction.
- Further research is needed to clarify the clinical and prognostic implications of RV dysfunction after CABG.
Abstract:
Objective. Right ventricular (RV) dysfunction after coronary artery bypass grafting (CABG) is associated with increased mortality and morbidity. In previous studies, the parameters of RV systolic function were mainly assessed, while the dynamics of RV diastolic function after surgery was practically not studied. The aim of this study was to study the dynamics of indicators of systolic and diastolic RV function after CABG as well as to identify factors associated with their presence. Methods. The study included 160 patients who underwent CABG and 36 volunteers with no history of coronary artery disease (CAD) as a control group. Echocardiographic examination of patients was performed to assess systolic and diastolic RV dysfunction before surgery and 18 months after CABG. A level of s’t < 10 cm/sec or TAPSE < 16 mm was considered as a sign of existing RV systolic dysfunction. RV diastolic dysfunction was defined as an Et/At ratio < 0.8 or >2.1 and/or an Et/et’ ratio > 6. Results. In CAD patients 18 months after CABG, there was an increase in the frequency of the right ventricular systolic (from 7.5% to 30%, p < 0.001) and diastolic (from 41.8% to 57.5%, p < 0.001) dysfunction. An increase in TAPSE (p = 0.007), a decrease in e’t (p = 0.005), and the presence of RV systolic dysfunction before surgery (p = 0.023) was associated with a significant increase in the likelihood of detecting RV systolic dysfunction 18 months after CABG (χ2(3) = 17.4, p = 0.001). High values of At before surgery (p = 0.021) and old myocardial infarction (p = 0.023) were significantly associated with an increased likelihood of detection of RV diastolic dysfunction 18 months after CABG (χ2(2) = 10.78, p = 0.005). Conclusions. This study demonstrated that in CAD patients 18 months after CABG, there was an increase in the frequency of right ventricular systolic and diastolic dysfunction. We also established the initial clinical, echocardiographic parameters, and perioperative complications associated with the presence of these changes in the postoperative period. The clinical and prognostic significance of the presence of systolic and/or diastolic RV dysfunction in patients 18 months after CABG remains to be explored.
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