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Comparison of the Effect on Vessel Density and RNFL between Carteolol and Latanoprost

Elena Nutterova1, Martin Fus2, Libuse Bartosova1

  • 1Ophthalmology Clinic JL, 155 00 Prague, Czech Republic.

Journal of Clinical Medicine
|July 27, 2022
PubMed

Insights

Carteolol and latanoprost both reduced intraocular pressure in hypertensive glaucoma patients. However, carteolol demonstrated a statistically significant improvement in retinal vessel density (VD), unlike latanoprost.

Area of Science:

  • Ophthalmology
  • Retinal Vascular Diseases
  • Glaucoma Research

Background:

  • Hypertensive glaucoma (HTG) requires effective early-stage treatment to prevent vision loss.
  • Assessing the impact of treatments on retinal microvasculature and neural tissue is crucial for understanding disease progression.

Purpose of the Study:

  • To compare the efficacy of carteolol versus latanoprost in early-stage hypertensive glaucoma.
  • To evaluate the treatment effects on intraocular pressure (IOP), retinal nerve fibre layer (RNFL), and vessel density (VD).

Main Methods:

  • A comparative study involving 46 eyes treated with carteolol and 52 eyes treated with latanoprost.
  • Evaluations included intraocular pressure (IOP), retinal nerve fibre layer (RNFL), vessel density (VD), and visual field tests.
  • Measurements were taken before treatment and at a 3-month follow-up.

Main Results:

  • Both carteolol and latanoprost significantly reduced IOP, with no statistically significant difference between the groups.
  • No significant differences in RNFL changes were observed between the carteolol and latanoprost groups.
  • A statistically significant improvement in vessel density (VD) was observed in the carteolol group compared to the latanoprost group.

Conclusions:

  • Carteolol and latanoprost are effective in lowering IOP in early hypertensive glaucoma.
  • Carteolol shows a superior effect on improving retinal vessel density (VD) compared to latanoprost.
  • Further research is warranted to explore the long-term implications of VD changes in glaucoma management.

Keywords:
OCTARNFLhypertensive glaucomatreatment with carteolol and latanoprostvessel density

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