Related Experiment Video

Updated: Sep 3, 2025

Electroencephalography Network Indices as Biomarkers of Upper Limb Impairment in Chronic Stroke
06:37

Electroencephalography Network Indices as Biomarkers of Upper Limb Impairment in Chronic Stroke

Published on: July 14, 2023

958

Blood Biomarkers for Triaging Patients for Suspected Stroke: Every Minute Counts

Radhika Kiritsinh Jadav1, Reza Mortazavi1,2, Kwang Choon Yee1

  • 1Faculty of Health, University of Canberra, Canberra, ACT 2617, Australia.

Journal of Clinical Medicine
|July 27, 2022
PubMed

Insights

Developing reliable blood biomarkers is crucial for early stroke diagnosis, especially in children and young adults. This review evaluates existing biomarkers to improve stroke detection and patient outcomes.

Area of Science:

  • Neurology
  • Biomarker Discovery
  • Clinical Diagnostics

Background:

  • Early stroke diagnosis is hindered by a lack of reliable blood biomarkers, leading to higher mortality and disability rates.
  • Current screening methods are less effective in young adults and children, causing diagnostic delays.
  • There is a critical need for accurate blood biomarkers for stroke triage across all age groups.

Purpose of the Study:

  • To review existing single blood biomarkers and biomarker panels for stroke prediction.
  • To analyze the sensitivity, specificity, clinical utility, and time-window of identified biomarkers.
  • To inform future research for developing more effective stroke diagnostic tools.

Main Methods:

  • A systematic literature review was conducted using PubMed and Web of Science.
  • Articles published in English between 2001 and 2021 concerning stroke biomarkers were included.
  • Comparative analysis of seven single biomarkers and five biomarker panels was performed.

Main Results:

  • The review identified and compared seven single biomarkers and five biomarker panels for stroke prediction.
  • Data on the availability, clinical usefulness, and time-window for each biomarker were compiled.
  • Sensitivity and specificity data were examined for their effectiveness in emergency stroke situations.

Conclusions:

  • Existing blood biomarkers show potential but require further validation for widespread clinical use.
  • The identified biomarkers and panels offer a foundation for developing improved stroke diagnostic strategies.
  • Enhanced biomarker research is essential to overcome current diagnostic challenges in stroke patients of all ages.

Keywords:
CNSbiomarkerchildrenhaemorrhagicischaemicpanelprediction valuessensitivityspecificitystroketriageyoung adults

More Related Videos

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies07:20

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies

Published on: January 28, 2014

36.7K
Prehospital Thrombolysis: A Manual from Berlin05:52

Prehospital Thrombolysis: A Manual from Berlin

Published on: November 26, 2013

22.0K

Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
326
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
212
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
21