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How Microbiomes Affect Skin Aging: The Updated Evidence and Current Perspectives.
Yanisa Ratanapokasatit1, Wannada Laisuan2, Teerapong Rattananukrom1
1Division of Dermatology, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand.
Life (Basel, Switzerland)
|July 27, 2022
Summary
The skin interactome, integrating genome, microbiome, and exposome, influences skin aging. Modulating the human microbiome offers future strategies to delay skin aging and improve skin health.
Area of Science:
- Dermatology and aging research.
- Microbiome science and its role in health.
- Integrative biology of skin aging.
Background:
- Skin aging is multifactorial, influenced by intrinsic and extrinsic factors, with oxidative damage and weakened antioxidant systems playing key roles.
- The human microbiome (gut and skin) is crucial for pathogen defense, inflammation modulation, and immune system regulation.
- Microbial dysbiosis, an alteration in microbial communities, is linked to various diseases, including aging.
Purpose of the Study:
- To review current evidence on the impact of human microbiomes on skin aging.
- To explore microbiome-related interventions for modulating skin health and aging.
- To highlight the significance of the skin interactome (genome-microbiome-exposome) in skin aging.
Main Methods:
- Literature review of scientific evidence.
- Analysis of the role of microbial communities in skin aging processes.
- Examination of potential therapeutic interventions targeting the microbiome.
Main Results:
- The human microbiome significantly affects skin aging.
- Alterations in the microbiome, or dysbiosis, are associated with aging and disease.
- The skin interactome model provides a framework for understanding skin aging.
Conclusions:
- Modulating the skin interactome, particularly the microbiome, is a promising future strategy for preventing and delaying skin aging.
- Probiotics show potential but require more clinical studies for anti-aging applications.
- Further research is needed to fully understand and leverage microbiome-based interventions for skin health.
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