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Updated: Sep 3, 2025

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
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Darier Disease with Psoriasis.

Seok-Young Kang1, So-Yeon Lee1, Jin-Seo Park1

  • 1Department of Dermatology, Kangnam Sacred Heart Hospital, Hallym University, Seoul 24252, Korea.

Medicina (Kaunas, Lithuania)
|July 27, 2022
PubMed
Summary

This case report details a rare instance of Darier disease co-occurring with psoriasis. Accurate diagnosis, potentially requiring repeat biopsy, is crucial for effective management of these distinct dermatoses.

Keywords:
Darier diseaseDarier-White diseasedyskeratosis folliculariskeratosis follicularispsoriasis

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Area of Science:

  • Dermatology
  • Genetics
  • Pathology

Background:

  • Darier disease is a rare autosomal dominant genodermatosis characterized by hereditary acantholytic dermatosis.
  • It typically presents with crusty patches, keratotic papules, and pruritus, predominantly in seborrheic areas.

Observation:

  • A 48-year-old male initially presented with symptoms suggestive of psoriasis vulgaris.
  • Initial treatment for psoriasis led to improvement, but subsequent worsening of lesions and new nail changes prompted further investigation.

Findings:

  • A second biopsy confirmed Darier disease, highlighting diagnostic challenges when co-occurring with other skin conditions like psoriasis.
  • The patient was treated with alitretinoin for Darier disease while continuing guselkumab for psoriasis.

Implications:

  • This case underscores the importance of considering Darier disease in patients with recalcitrant or atypical dermatoses, even after initial diagnosis and treatment.
  • Co-occurrence of Darier disease and psoriasis is rare, necessitating careful histopathological evaluation for accurate diagnosis and tailored therapeutic strategies.