Allergic Contact Cell-Mediated Hypersensitivity in Psoriasis: A Narrative Minireview

Area of Science:

• Dermatology
• Immunology
• Allergology

Background:

• Psoriasis involves a compromised skin barrier, increasing susceptibility to contact allergens.
• Allergic contact hypersensitivity shares T-cell-mediated mechanisms with psoriasis.
• This overlap suggests a potential comorbidity between the two conditions.

Purpose of the Study:

• To highlight the link between psoriasis and allergic contact hypersensitivity.
• To recommend diagnostic considerations for dermatologists and allergists.

Main Methods:

• Review of existing literature on psoriasis pathophysiology and contact dermatitis.
• Analysis of T-cell-mediated immune responses in both conditions.

Main Results:

• Dysfunctional skin barrier in psoriasis facilitates allergen penetration.
• Patients with psoriasis are at increased risk for allergic contact hypersensitivity.
• Clinical presentation may mimic or overlap with psoriasis, especially in palmoplantar regions or during biologic therapy.

Conclusions:

• Allergic contact hypersensitivity should be considered in specific psoriasis patient cohorts.
• Screening is advised for patients with refractory palmoplantar psoriasis or those on biologics with suspected contact dermatitis.
• Integrated dermatological and allergological assessment is crucial for accurate diagnosis and management.