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Related Concept Videos

Burn Injuries01:22

Burn Injuries

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Burn injuries occur when the skin and underlying tissues are damaged due to exposure to heat, electricity, chemicals, radiation, or friction. They can vary in severity, from minor superficial burns to severe deep burns that can be life-threatening.
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
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Phases of Wound Repair01:28

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Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
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Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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Peripheral Artery Disease IV: Nursing Management01:26

Peripheral Artery Disease IV: Nursing Management

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 The nursing management of a patient with peripheral artery disease (PAD) begins with a thorough assessment of the patient’s health history and clinical manifestations.AssessmentHealth History: Evaluate the patient’s history of hypertension, hyperlipidemia, family history of cardiovascular issues, and lifestyle factors such as dietary patterns, smoking, and physical activity.Physical Examination:Assess the affected extremity for decreased or absent peripheral pulses,...
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Methods of reducing fever01:22

Methods of reducing fever

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The signs and symptoms of fever include hot and dry skin, flushed face, thirst, muscle aches, anorexia, headache, tachycardia, tachypnea, and fatigue. Elevated body temperature is reduced using two methods: pharmacological and nonpharmacological. Proper identification and treatment of the root cause of a fever is of utmost importance.
Pharmacological Methods of Reducing Fever:
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Decreased Body Temperature01:29

Decreased Body Temperature

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A decreased body temperature can occur in patients with hypothermia and frostbite. Heat loss with extended cold exposure overpowers the body's ability to create heat, resulting in hypothermia. Core temperature readings help classify hypothermia. Mild hypothermia is temperatures between 32 °C (89.6 °F) and 35°C (95 °F) and is caused by impaired thermoregulation. Moderate hypothermia is temperatures between 28 C (82.4 °F) and 32 °C (89.6 °F) caused by...
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Updated: Sep 3, 2025

Author Spotlight: A Multi-Depth Porcine Model for Comprehensive Study of Burn Injuries and Healing Processes
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Author Spotlight: A Multi-Depth Porcine Model for Comprehensive Study of Burn Injuries and Healing Processes

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Therapeutic Strategies to Reduce Burn Wound Conversion.

Alen Palackic1,2, Jayson W Jay1, Robert P Duggan1

  • 1Department of Surgery, University of Texas Medical Branch, Galveston, TX 77555, USA.

Medicina (Kaunas, Lithuania)
|July 27, 2022
PubMed
Summary

Burn wound conversion, where superficial burns deepen, lacks effective treatments. This review explores novel biologic therapies like stem cells and biomaterials to address this critical issue.

Keywords:
biologicsburnsinflammationwounds and injuries

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Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Wound Healing Research

Background:

  • Burn wound conversion is a critical clinical challenge where initially superficial burns deepen, necessitating surgical intervention.
  • Current treatments for burn wound conversion are insufficient, highlighting the urgent need for novel therapeutic strategies.
  • Existing research has targeted individual molecular mechanisms (e.g., ischemia, inflammation, apoptosis) but lacks comprehensive approaches.

Purpose of the Study:

  • To review the pathophysiology of burn wound conversion.
  • To highlight recent advancements in therapeutic interventions, particularly the use of biologics.
  • To identify future research directions for mitigating burn wound conversion.

Main Methods:

  • Literature review focusing on molecular mechanisms of burn wound conversion.
  • Analysis of studies investigating biologics, including mesenchymal stem cells, biomaterials, and immune regulators.
  • Synthesis of current knowledge on pathophysiology and emerging treatments.

Main Results:

  • Burn wound conversion involves complex molecular pathways including ischemia, inflammation, apoptosis, autophagy, oxidative stress, hypothermia, and dehydration.
  • Emerging biologic therapies show promise in addressing multiple mechanisms of burn wound conversion.
  • Mesenchymal stem cells, advanced biomaterials, and immune modulators are key areas of recent investigation.

Conclusions:

  • There is a critical need for therapeutic strategies that address the multifaceted nature of burn wound conversion.
  • Biologics offer a promising avenue for developing more effective treatments by targeting multiple underlying mechanisms.
  • Further research into the mechanistic pathways, safety, and efficacy of these novel treatments is essential for clinical translation.