Related Experiment Video
Updated: Sep 3, 2025
06:28
A Chronic High-Intensity Interval Training and Diet-Induced Obesity Model to Maximize Exercise Effort and Induce Physiologic Changes in Rats
Published on: April 28, 2023
941
Sustained Endurance Training Leads to Metabolomic Adaptation
Astrid Weiss1, Katharina Alack2, Stephan Klatt3
1German Center for Lung Research (DZL), Cardio-Pulmonary Institute (CPI), Justus-Liebig-University, 35390 Giessen, Germany.
Metabolites
|July 27, 2022
Summary
Endurance training alters resting metabolism in athletes, affecting lipids and bile acids. These changes in metabolites may contribute to the cardiovascular benefits observed in endurance athletes.
Area of Science:
- Exercise physiology and metabolomics.
Background:
- Endurance training (ET) significantly impacts substrate metabolism, particularly glycogen conservation.
- Understanding metabolic adaptations in highly trained individuals is crucial for comprehending exercise physiology and cardiovascular health.
Purpose of the Study:
- To investigate differences in lipid, lipid-like substance, and amino acid metabolism between endurance-trained (ET) and untrained (UT) subjects.
- To identify specific metabolites that vary at rest in ET individuals.
Main Methods:
- Targeted metabolomics analysis of 345 metabolites in plasma from ET and UT subjects.
- Utilized liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS).
- Categorized subjects based on maximum relative oxygen uptake (VO2max).
Main Results:
- Differentially regulated acylcarnitines and glycerophosphocholines (GPCs) were observed in ET vs. UT subjects.
- Alterations in bile acids, including down-regulation of TCDCA and up-regulation of specific bile acid ratios, were noted in ET individuals.
- Polyunsaturated fatty acids (PUFAs) and specific lipid mediators showed altered concentrations, with some metabolites correlating with VO2max.
Conclusions:
- Endurance training leads to distinct resting metabolic profiles, characterized by variations in phospholipids, acylcarnitines, bile acids, and PUFAs.
- These metabolic adaptations in endurance athletes may underlie their improved cardiovascular risk profile.
More Related Videos
Related Concept Videos
01:27Exercise and Muscle Performance
1.6K
Exercise induces a range of adaptations in muscle tissue, depending on the type and duration of activity. Such physical training can be broadly categorized into two types: endurance exercises and resistance exercises.
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...
1.6K
01:24Metabolic States of the Body: Fasting and Starvation
1.7K
During the initial hours of fasting, the body uses up its glycogen stores as an energy source. Once these glycogen reserves are depleted, the body begins breaking down stored triglycerides and structural proteins. During this stage, glycerol becomes a key substrate for gluconeogenesis, while free fatty acids undergo beta-oxidation to provide energy for tissues, such as skeletal muscle. In the fasting state, the body spares protein breakdown as much as possible to conserve muscle and structural...
1.7K
01:18Metabolic States of the Body: The Postabsorptive State
513
The postabsorptive state usually starts about four hours after a meal and lasts until the next meal is eaten. During this time, the digestive system stops absorbing nutrients, and the body uses stored energy reserves to maintain stable blood glucose levels.
Initially, glycogen stored in the liver is broken down to release glucose into the bloodstream, while glycogen in the muscles is broken down to supply glucose for energy directly within the muscle cells. As glycogen stores diminish,...
Initially, glycogen stored in the liver is broken down to release glucose into the bloodstream, while glycogen in the muscles is broken down to supply glucose for energy directly within the muscle cells. As glycogen stores diminish,...
513
00:52What is Metabolism?
117.2K
Overview
117.2K
01:24Muscle Recovery and Fatigue
2.4K
Muscle fatigue refers to the decline in a muscle's ability to maintain the force of contraction after prolonged activity. It primarily stems from changes within muscle fibers. Even before experiencing muscle fatigue, one may feel tired and have the urge to stop the activity. This response, known as central fatigue, occurs due to changes in the central nervous system, namely the brain and spinal cord. While there is no single mechanism that induces fatigue, it may serve as a protective...
2.4K