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Unraveling the Diversity of Co-Colonization by CPE

Gabrielle Levi1, Mor Lurie-Weinberger1, Alona Keren-Paz1

  • 1National Institute for Antibiotic Resistance and Infection Control, Ministry of Health, Tel Aviv 6423906, Israel.

Microorganisms
|July 27, 2022
PubMed

Insights

Carbapenem-producing Enterobacterales (CPE) co-colonization, driven by horizontal gene transfer and transmission, is a growing concern. Understanding these mechanisms is crucial for managing antibiotic resistance.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Genetics

Background:

  • Rising global prevalence of antibiotic-resistant bacteria, particularly carbapenem-producing Enterobacterales (CPE).
  • CPE detection remains infrequent in many high-income nations despite increasing resistance.
  • Co-colonization with distinct CPE strains or multiple carbapenemase enzymes presents a complex challenge.

Observation:

  • Three clinical cases illustrating CPE co-colonization mechanisms.
  • Focus on horizontal gene transfer (HGT) as a key driver.
  • Demonstration of patient-to-patient transmission events.

Findings:

  • Detailed insights into the molecular mechanisms enabling co-colonization.
  • Evidence of diverse CPE species involved in co-colonization events.
  • Identification of HGT and transmission pathways facilitating CPE spread.

Implications:

  • Enhanced understanding of CPE epidemiology and evolution.
  • Potential for improved diagnostic and infection control strategies.
  • Highlights the need for vigilance in detecting and managing co-colonization to curb resistance.
Keywords:
CPECREHGTco-colonization

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