Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Drug Delivery: Miscellaneous Routes

Drug Delivery: Miscellaneous Routes

Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...

Drug Delivery: Overview

Drug Delivery: Overview

The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...

Drug Delivery: Parenteral Route

Drug Delivery: Parenteral Route

The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...

Factors Influencing Drug Absorption: Pharmaceutical Parameters

Factors Influencing Drug Absorption: Pharmaceutical Parameters

Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Carbon Nanotube Hydrogel Electrodes for High-Fidelity Intra-Aural EEG in Wearable Neurotechnology.

Sensors (Basel, Switzerland)·2026

Same author

Crosslinking-Dependent Design of Hyaluronic Acid Matrices for Enhanced Bioadhesion and Cellular Response.

Pharmaceutics·2026

Same author

Design and Application of a Sawdust-Alginate Biocomposite for Sustainable Cationic Dyes Removal from Aqueous Solutions.

Polymers·2026

Same author

Monitoring Environmental Glyphosate in Northeastern Romania and Its Cytotoxic Impact on Human Fibroblasts.

Journal of xenobiotics·2026

Same author

Biocompatible Photocrosslinked Chitosan- and Gelatin-Based Hydrogels for Wound Healing Applications.

Gels (Basel, Switzerland)·2026

Same author

From LQ to AI-BED-Fx: A Unified Multi-Fraction Radiobiological and Machine-Learning Framework for Gamma Knife Radiosurgery Across Intracranial Pathologies.

Cancers·2026

Search research articles

Related Experiment Video

Updated: Sep 3, 2025

Spatio-Temporal In Vivo Imaging of Ocular Drug Delivery Systems using Fiberoptic Confocal Laser Microendoscopy

Spatio-Temporal In Vivo Imaging of Ocular Drug Delivery Systems using Fiberoptic Confocal Laser Microendoscopy

Published on: September 27, 2021

Drug-Loaded Polymeric Particulated Systems for Ophthalmic Drugs Release.

Ruxandra Mihailovici¹, Alexandra Croitoriu^1,2, Florin Nedeff³

¹Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, Romania.

Molecules (Basel, Switzerland)

|July 27, 2022

Summary

This summary is machine-generated.

New biodegradable polymeric nanoparticles effectively deliver drugs to the eye, maintaining therapeutic levels longer. These systems, utilizing chitosan and other biopolymers, show promise for enhanced ocular drug delivery and treatment efficacy.

Keywords:

fractal mathematical model ophthalmic drugs particle-based drug delivery pre-emulsions routes of administration

More Related Videos

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

Published on: August 28, 2015

Ocular Therapeutic Delivery and Advanced Tissue Retrieval in Adult Rats

Ocular Therapeutic Delivery and Advanced Tissue Retrieval in Adult Rats

Published on: May 23, 2025

Related Experiment Videos

Last Updated: Sep 3, 2025

Spatio-Temporal In Vivo Imaging of Ocular Drug Delivery Systems using Fiberoptic Confocal Laser Microendoscopy

Spatio-Temporal In Vivo Imaging of Ocular Drug Delivery Systems using Fiberoptic Confocal Laser Microendoscopy

Published on: September 27, 2021

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

Published on: August 28, 2015

Ocular Therapeutic Delivery and Advanced Tissue Retrieval in Adult Rats

Ocular Therapeutic Delivery and Advanced Tissue Retrieval in Adult Rats

Published on: May 23, 2025

Area of Science:

Ophthalmic drug delivery
Polymeric nanoparticles
Biomaterials science

Background:

Ocular drug delivery faces significant challenges due to the eye's protective barriers and clearance mechanisms.
Developing effective systems for sustained drug release in the anterior and posterior eye segments is crucial for treating various ocular conditions.

Purpose of the Study:

To prepare and characterize novel drug-loaded biodegradable polymeric nanoparticles for improved ocular drug delivery.
To evaluate the drug release kinetics and interactions between drug molecules and the polymeric matrix.

Main Methods:

Preparation of pre-emulsion coated with biodegradable polymers (chitosan, sodium hyaluronate, heparin sodium).
Characterization of nanoparticles (size: 190-270 nm, zeta potential: -37 mV to +24 mV).
In vitro drug release studies with dexamethasone, pilocarpine, and bevacizumab, coupled with extensive fractal modeling analysis.

Main Results:

Successfully synthesized nanoparticles with controlled size and surface charge based on biopolymer selection.
Demonstrated safe and effective drug release, maintaining therapeutic concentrations over extended periods.
Fractal modeling revealed complex drug-polymer interactions, particularly with bevacizumab, and identified a 'Kink' type release mode.

Conclusions:

Biodegradable polymeric nanoparticles offer a promising platform for sustained and effective ocular drug delivery.
The choice of biopolymer significantly influences nanoparticle characteristics and drug release profiles.
Advanced modeling techniques provide insights into the complex dynamics of drug release from these novel systems.