Antimicrobial Properties of Silver-Modified Denture Base Resins

Area of Science:

• Biomaterials Science
• Oral Microbiology
• Nanotechnology

Background:

• Denture base resins are susceptible to microbial colonization by Candida albicans and Staphylococcus aureus, leading to oral infections like denture stomatitis.
• Silver nanoparticles (AgNPs) show promise in dentistry for inhibiting bacterial adhesion, proliferation, and biofilm formation.

Purpose of the Study:

• To synthesize cold and heat-curing denture base resins modified with AgNPs and silver chloride (AgCl).
• To evaluate the antimicrobial potential of these modified resins against C. albicans and S. aureus.

Main Methods:

• Resin synthesis and characterization using Fourier transform infrared spectroscopy (FTIR).
• Antimicrobial activity assessment via disc-diffusion and microdilution methods, including a modified broth method with viable counting.

Main Results:

• FTIR confirmed the successful incorporation of AgNPs and AgCl into the denture base resins.
• The modified resins demonstrated significant antimicrobial effects against both C. albicans and S. aureus.

Conclusions:

• Denture base resins modified with AgNPs and AgCl exhibit antimicrobial properties.
• These modified resins hold potential for preventing and treating oral infections caused by staphylococci and candida, especially in vulnerable populations like the elderly.