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Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
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Peptic ulcer disease, commonly called PUD, represents a multifaceted condition characterized by disruptions in the lining of the gastrointestinal (GI)  tract. Central to the protection of the gastrointestinal lining is the mucosal-bicarbonate barrier. This physiological defense mechanism is a formidable shield against the corrosive effects of gastric acid and pepsin secretion in the stomach. Its role is pivotal in maintaining the structural integrity of the stomach's inner lining.
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Gut Microbiota in Psoriasis.

Mihaela Cristina Buhaș1, Laura Ioana Gavrilaș2, Rareș Candrea3

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Psoriasis involves chronic inflammation and altered gut microbiota. Targeting the gut microbiome with diet, probiotics, or prebiotics shows promise for managing this autoimmune skin condition.

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Area of Science:

  • Dermatology
  • Immunology
  • Microbiome Research

Background:

  • Psoriasis is a chronic inflammatory skin disease with autoimmune features.
  • Chronic inflammation leads to uncontrolled keratinocyte growth and impaired differentiation.
  • The gut microbiota's role in immune regulation offers new insights into psoriasis pathogenesis.

Purpose of the Study:

  • To review current scientific evidence on gut microbiome alterations in psoriasis patients.
  • To highlight state-of-the-art microbiome-targeted therapies for psoriasis.
  • To explore the potential of microbiome modulation as a therapeutic strategy for psoriasis.

Main Methods:

  • Literature review of recent studies on psoriasis and gut microbiota.
  • Analysis of evidence regarding dietary interventions, probiotics, and prebiotics.
  • Synthesis of findings on microbiome alterations and targeted therapies.

Main Results:

  • Psoriatic patients exhibit distinct gut microbiome alterations.
  • Dietary approaches, probiotics, and prebiotics can modulate the gut microbiota.
  • These modulations show potential as novel therapeutic avenues for psoriasis.

Conclusions:

  • Gut microbiome alterations are implicated in psoriasis pathogenesis.
  • Microbiome-targeted therapies represent a promising frontier for psoriasis prevention and treatment.
  • Further research is warranted to optimize these therapeutic strategies.