Biomaterial-Based Therapeutic Strategies for Obesity and Its Comorbidities

Jing Li1, Hongli Duan1, Yan Liu1

  • 1School of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing 400054, China.

Pharmaceutics
|July 27, 2022
PubMed

Insights

Obesity treatments face challenges with current drugs. Emerging strategies, particularly biomaterials for targeted delivery, offer promising new avenues for combating obesity and its associated health issues.

Area of Science:

  • Biomaterials Science
  • Pharmacology
  • Public Health

Background:

  • Obesity is a significant global health problem, leading to serious comorbidities like type 2 diabetes and cardiovascular disease.
  • Current pharmacotherapies for obesity have limitations including poor bioavailability, specificity, and toxicity.
  • Approved anti-obesity medications are few, highlighting the need for novel therapeutic approaches.

Purpose of the Study:

  • To review emerging obesity treatment strategies, focusing on the role of biomaterials.
  • To analyze the functions and applications of biomaterials in targeted obesity treatment.
  • To discuss future prospects and challenges in biomaterial-based obesity therapies.

Main Methods:

  • Systematic review and analysis of current obesity treatment strategies.
  • Evaluation of small-molecule drugs, natural products, and biotechnological drugs.
  • In-depth examination of biomaterial applications in obesity management.

Main Results:

  • Biomaterials show advanced functions for targeted delivery in obesity treatment.
  • Biomaterials exhibit significant biological activities and therapeutic potential.
  • Emerging strategies integrate materials science, chemistry, and biotechnology for obesity care.

Conclusions:

  • Biomaterial-based strategies represent a promising frontier in obesity treatment.
  • Further research is needed to overcome challenges in biomaterial development and application.
  • Multidisciplinary integration is key to advancing novel obesity therapeutics.

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