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Updated: Sep 3, 2025

Multidisciplinary Approach to Obesity Management: A Case Report
Published on: May 30, 2025
Biomaterial-Based Therapeutic Strategies for Obesity and Its Comorbidities
Jing Li1, Hongli Duan1, Yan Liu1
1School of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing 400054, China.
Abstract:
Obesity is a global public health issue that results in many health complications or comorbidities, including type 2 diabetes mellitus, cardiovascular disease, and fatty liver. Pharmacotherapy alone or combined with either lifestyle alteration or surgery represents the main modality to combat obesity and its complications. However, most anti-obesity drugs are limited by their bioavailability, target specificity, and potential toxic effects. Only a handful of drugs, including orlistat, liraglutide, and semaglutide, are currently approved for clinical obesity treatment. Thus, there is an urgent need for alternative treatment strategies. Based on the new revelation of the pathogenesis of obesity and the efforts toward the multi-disciplinary integration of materials, chemistry, biotechnology, and pharmacy, some emerging obesity treatment strategies are gradually entering the field of preclinical and clinical research. Herein, by analyzing the current situation and challenges of various new obesity treatment strategies such as small-molecule drugs, natural drugs, and biotechnology drugs, the advanced functions and prospects of biomaterials in obesity-targeted delivery, as well as their biological activities and applications in obesity treatment, are systematically summarized. Finally, based on the systematic analysis of biomaterial-based obesity therapeutic strategies, the future prospects and challenges in this field are proposed.
Insights
Obesity treatments face challenges with current drugs. Emerging strategies, particularly biomaterials for targeted delivery, offer promising new avenues for combating obesity and its associated health issues.
Area of Science:
- Biomaterials Science
- Pharmacology
- Public Health
Background:
- Obesity is a significant global health problem, leading to serious comorbidities like type 2 diabetes and cardiovascular disease.
- Current pharmacotherapies for obesity have limitations including poor bioavailability, specificity, and toxicity.
- Approved anti-obesity medications are few, highlighting the need for novel therapeutic approaches.
Purpose of the Study:
- To review emerging obesity treatment strategies, focusing on the role of biomaterials.
- To analyze the functions and applications of biomaterials in targeted obesity treatment.
- To discuss future prospects and challenges in biomaterial-based obesity therapies.
Main Methods:
- Systematic review and analysis of current obesity treatment strategies.
- Evaluation of small-molecule drugs, natural products, and biotechnological drugs.
- In-depth examination of biomaterial applications in obesity management.
Main Results:
- Biomaterials show advanced functions for targeted delivery in obesity treatment.
- Biomaterials exhibit significant biological activities and therapeutic potential.
- Emerging strategies integrate materials science, chemistry, and biotechnology for obesity care.
Conclusions:
- Biomaterial-based strategies represent a promising frontier in obesity treatment.
- Further research is needed to overcome challenges in biomaterial development and application.
- Multidisciplinary integration is key to advancing novel obesity therapeutics.
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