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Related Concept Videos

Viral Structure00:56

Viral Structure

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Viruses are extraordinarily diverse in shape and size, but they all have several structural features in common. All viruses have a core that contains a DNA- or RNA-based genome. The core is surrounded by a protective coat of proteins called the capsid. The capsid is composed of subunits called capsomeres. The capsid and genome-containing core are together known as the nucleocapsid.
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Intracellular Movement of Viruses and Bacteria01:10

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Intracellular bacteria and viruses often comprise a group of highly infectious pathogens that can cause several diseases. Bacterial pathogens include those belonging to the genus Rickettsia responsible for conditions such as rocky mountain spotted fever and the Mediterranean spotted fever; Chlamydia, a genus responsible for a sexually transmitted disease; Coxiella burnetii, an agent responsible for Q fever. Viral pathogens include vaccinia—a poxvirus, and herpes simplex virus—a...
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Protein Complex Assembly02:41

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Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types.  Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
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Size and Structure of Viral Genomes01:26

Size and Structure of Viral Genomes

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Viral genomes exhibit remarkable diversity in size, structure, and composition, influencing their replication strategies and interactions with host cells. These genomes consist of either DNA or RNA and may be linear or circular. Additionally, they can be single-stranded or double-stranded, with each configuration affecting how the virus propagates within a host. RNA viruses, for instance, generally have smaller genomes than DNA viruses, a factor that contributes to their high mutation rates and...
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Related Experiment Video

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Advancing High-Resolution Imaging of Virus Assemblies in Liquid and Ice
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Nipah Virus Infection Generates Ordered Structures in Cellulo.

Cecilia Alejandra Vázquez1, Lina Widerspick2,3, Roland Thuenauer4,5

  • 1Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales (IQUIBICEN), Consejo Nacional de Investigaciones Científicas y Técnicas-Universidad de Buenos Aires, Ciudad Universitaria, 1428 Buenos Aires, Argentina.

Viruses
|July 27, 2022
PubMed
Summary

Nipah virus (NiV) infection causes unique intracellular structures. These NiV-specific structures, observed at the cell periphery, may offer new targets for antiviral therapies against this deadly zoonotic virus.

Keywords:
CLEMNipah virusSEMSIMTEMin celluloordered structures

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Area of Science:

  • Virology
  • Cell Biology
  • Pathogenesis

Background:

  • Nipah virus (NiV) is a highly fatal zoonotic paramyxovirus.
  • Mechanisms of NiV pathogenesis are not fully understood.
  • NiV counteracts host immune responses during infection.

Purpose of the Study:

  • To characterize the intracellular structures formed during NiV infection.
  • To investigate the specificity and kinetics of these structures.
  • To explore potential antiviral targets.

Main Methods:

  • Structured Illumination Microscopy (SIM)
  • Transmission Electron Microscopy (TEM)
  • Scanning Electron Microscopy (SEM)
  • Correlative Light and Electron Microscopy (CLEM)

Main Results:

  • NiV infection induces the formation of specific ordered intracellular structures.
  • These structures are unique to NiV and not observed with other viruses.
  • The structures appear with defined kinetics and localize to the cellular periphery.

Conclusions:

  • NiV infection involves a novel cytopathogenic mechanism.
  • The described NiV-specific structures offer new insights into viral biology.
  • These structures represent potential targets for novel antiviral strategies.