Related Experiment Video
Updated: Sep 3, 2025

Investigating Bacterial-Fungal Interactions using Fungal Highway Columns in Diverse Environments and Substrates
Published on: January 24, 2025
FunOMIC: Pipeline with built-in fungal taxonomic and functional databases for human mycobiome profiling
Zixuan Xie1,2, Chaysavanh Manichanh1,2
1Microbiome Lab, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Barcelona Hospital Campus, Passeig Vall d'Hebron 119-129, 08035 Barcelona, Spain.
Abstract:
While analysis of the bacterial microbiome has become routine, that of the fungal microbiome is still hampered by the lack of robust databases and bioinformatic pipelines. Here, we present FunOMIC, a pipeline with built-in taxonomic (1.6 million marker genes) and functional (3.4 million non-redundant fungal proteins) databases for the identification of fungi. Applied to more than 2,600 human metagenomic samples, the tool revealed fungal species associated with geography, body sites, and diseases. Correlation network analysis provided new insights into inter-kingdom interactions. With this pipeline and two of the most comprehensive fungal databases, we foresee a fast-growing resource for mycobiome studies.
Related Concept Videos
Applications of Molecular Taxonomy
Fungal Phylum Microsporidia
Overview of Fungi
Fungal Phylum Basidiomycota
Comparing Mitochondrial, Chloroplast, and Prokaryotic Genomes
Modern Molecular Taxonomy

